韩园园,博士,特聘副研究员,运用微生物学、分子生物学、细胞生物学、动物行为学、电生理、多组学分析等手段开展情绪障碍、疾病模型情绪障碍的发病机制研究及药物开发;已完成并发表 SCI 论文 14 篇,其中第一或共同第一作者、 通讯作者 8 篇,分别发表在 Brain, Behavior, and Immunity、CNS Neuroscience & Therapeutics、Phytomedicine、Journal of Neurochemistry 等国际杂志。主持中国博士后科 学基金面上资助、广东省自然科学基金面上项目、广州市基础与应用基础研究项目。
论文专著(#第一作者,*通讯作者):
1. Han YY, Jin K, Pan QS, Li B, Wu ZQ, Gan L, Yang L*, Long C*. Microglial activation in the dorsal striatum participates in anxiety-like behavior in Cyld knockout mice. Brain, Behavior, and Immunity. 2020, 89:326-338
2. Huang SY#, Su ZY#, Han YY#, Liu L, Li CH*. Cordycepin improved the cognitive function through regulating adenosine A2A receptors in MPTP induced Parkinson's disease mice model. Phytomedicine. 2023,110:154649
3. Zhang PP, He XP, Chen HW*, Han YY*. Alterations in vaginal microbiota in uterine fibroids patients with ultrasound- guided high-intensity focused ultrasound ablation. Frontiers in Microbiology. 2023.1138962
4. Han YY #, Chen ZH#, Shang YJ, Yan WW, Wu BY, Li CH*. Cordycepin improves behavioral-LTP and dendritic structure in hippocampal CA1 area of rats. Journal of Neurochemistry. 2019, 151: 79-90
5. Chen ZH#, Han YY #, Shang YJ, Zhuang SY, Huang JN, Wu BY, Li CH*. Cordycepin ameliorates synaptic dysfunction and dendrite morphology damage of hippocampal CA1 via A1R in cerebral ischemia. Frontiers in Cellular Neuroscience. 2021,15:783478
6. Han YY, Zhou JW, Zhang ZY, Guo ZW, Wu ZQ, Liu DX*, Long C*. Multiple brain regions are involved in anxiety alleviation in Cyld knockout mice induced by acute stress. Stress. 2023, 26,2228925.
7. Han YY, Li K, Hu JY, Wu JC, Li X, Li CH*. Gender differences in dendritic damage, gut microbiota dysbiosis and cognitive impairment during aging processes. CNS Neuroscience & Therapeutics. 2024, 2024, 30(12) (
8. Han YY, Wang XD, Liu L, Guo HM, Cong W, Yan WW, Huang JN, Xiao P, Li CH*. L- type VDCCs participate in behavioral-LTP and memory retention. Neurobiol Learn Mem. 2017, 145: 75-83.
9. Kong H, Han YY, Yang GL, Li K, Yu L, Xie XK, Xia GY, Wei PJ, Zhang WR, Li CH. Tenuifolin improves learning and memory by regulating long-term potentiation and dendritic structure of hippocampal CA1 area in healthy female mice but not male mice. Behav Brain Res. 2024 May 28; 466:114974.
10. Cao ZP#, Dai D#, Wei PJ, Han YY, Guan YQ, Li HH, Liu WX, Xiao P, Li CH*. Effects of cordycepin on spontaneous alternation behavior and adenosine receptors expression in hippocampus. Physiology & Behavior. 2018,184:135-142.
11. Jiang JX, Tang BL, Wang L, Huo QW, Tan SY, Misrani, AM, Han YY, …… Long C, Yang L. (2022). Systemic LPS-induced microglial activation results in increased GABAergic tone: A mechanism of protection against neuroinflammation in the medial prefrontal cortex in mice. Brain Behav Immun.2022. 99, 53-69.
12. Zhang ZY, Li JH, Long C, Han YY, Fan J, Misrani AM, Ji XY. Regulatory Mechanism of circEIF4G2 Targeting miR-26a in Acute Myocardial Infarction. Journal of Healthcare Engineering, 2022, 5308372.
13. Zhang ZY, Luo W, Han YY, Misrani, A, Chen HW, Long C. Effect of microRNA-455-5p (miR-455-5p) on the Expression of the Cytokine Signaling-3 (SOCS3) Gene During Myocardial Infarction. J Biomed Nanotechnol, 2022 18(1), 202-210.
14. Pan HH, Han YY, Huang JG, Yu XT, Jiao CW, Yang XB, Preet Dhaliwal, Xie YZ, Yang BB, Purification and identification of a polysaccharide from medicinal mushroom Amauroderma rude with immunomodulatory activity and inhibitory effect on tumor growth. Oncotarget. 2015, 6(19):17777-17791