副研究员,硕士生导师。研究方向为利用斑马鱼从事基因编辑技术、水生动物性状发育与进化、人类疾病模型构建及药物高通量筛选研究。主持国家自然科学基金青年项目、中国博士后科学基金特别资助项目、广东省自然科学基金面上项目等省部级以上科研项目十余项,获授权发明专利1项,以第一作者或通讯作者(含共同)在Nature Communications(2022, 2024)、Aquaculture(2021, 2023)、BMC Genomics(2020)、Cell Research(2015)等主流刊物上发表论文十余篇。
[1] Fang Liang, Yu Zhang, Lin Li, Yexin Yang, Ji-Feng Fei, Yanmei Liu*, Wei Qin*. SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish. NATURE COMMUNICATIONS, 2022.
[2] Wei Qin#, Fang Liang#, Sheng-Jia Lin, Cassidy Petree, Kevin Huang, Yu Zhang, Lin Li, Pratishtha Varshney, Philippe Mourrain, Yanmei Liu*, Gaurav K. Varshney*. ABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish. NATURE COMMUNICATIONS, 2024.
[3] Wei Qin#, Fang Liang#, Yan Feng, Haipeng Bai, Ruibin Yan, Song Li, Shuo Lin. Expansion of CRISPR/Cas9 genome targeting sites in zebrafish by Csy4-based RNA processing. CELL RESEARCH, 2015.
[4] Fang Liang, Zijiong Dong, Jianmin Ye, Wei Hu, Ramji Kumar Bhandari, Kangsen Mai, Xuegeng Wang*. In vivo DNA methylation editing in zebrafish. EPIGENETICS-US, 2023.
[5] Zijiong Dong, Jiadong Li, Ruhuang Deng, Zhenzhen Zhang, Jianlin Chen, Yang Lei, Liting Wu, Zheng Guo, Bei Wang, Bingxi Li, Fang Liang*, Jianmin Ye*. TLR5M cooperates with TLR5S to activate NF-kappa B in Nile tilapia (Oreochromis niloticus). AQUACULTURE, 2023.
[6] Fang Liang#, Xiaochan Lu#, Biyu Wu, Yexin Yang, Wei Qin*. Nucleolar protein 56 deficiency in zebrafish leads to developmental abnormalities and anemia via p53 and JAK2-STAT3 signaling. BIOLOGY-BASEL, 2023.
[7] Zijiong Dong, Bingxi Li, Liting Wu, Yang Lei, Jianlin Chen, Liangliang Mu, Hairong Wu, Meng Chen, Bei Wang, Jianmin Ye*, Fang Liang*. Identification and characterization of scavenger receptor class B member 2 in Nile tilapia (Oreochromis niloticus). AQUACULTURE REPORTS, 2021.
[8] Yunxing Liu#, Fang Liang#, Zijiong Dong, Song Li*, Jianmin Ye*, Wei Qin*. Genome editing in zebrafish by ScCas9 recognizing NNG PAM. CELLS-BASEL, 2021.
[9] Haipeng Bai, Lijun Liu, Ke An, Xiaochan Lu, Michael Harrison, Yanqiu Zhao, Ruibin Yan, Zhijie Lu, Song Li, Shuo Lin, Fang Liang*, Wei Qin*. CRISPR/Cas9-mediated precise genome modification by a long ssDNA template in zebrafish. BMC GENOMICS, 2020.
[10] Bingxi Li, Yanjian Yang, Yuan Li, Liting Wu, Siwei Wu, Zijiong Dong, Meng Chen, Fang Liang*, Zheng Guo, Bei Wang*, Jianmin Ye*. CD40 plays roles in T cell-dependent response and B cell activation and differentiation in Nile tilapia (Oreochromis niloticus). AQUACULTURE, 2021.
[11] Bingxi Li, Yuan Li, Siwei Wu, Yanjian Yang, Shengli Fu, Xiaoxue Yin, Xiao Tu, Fang Liang*, Zheng Guo*, Jianmin Ye*. Identification and functional characterization of CD154 in T cell-dependent immune response in Nile tilapia (Oreochromis niloticus). FISH & SHELLFISH IMMUNOLOGY, 2021.
[12] Fang Liang#, Yuxiang Han#, Hao Gao*, Shengchang Xin, Shaodan Chen, Nan Wang, Wei Qin, Hanbing Zhong, Shuo Lin, Xinsheng Yao, Song Li*. Kaempferol identified by zebrafish assay and fine fractionations strategy from Dysosma versipellis inhibits angiogenesis through VEGF and FGF pathways. SCIENTIFIC REPORTS, 2015.