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  • 性别：男
  • 职称：教授
  • 学历：博士
  • 学科：生理学、神经生物学
个人简历

    1994年在华南师范大学生物系获博士学位。1994-1996年在华东师范大学生物系从事博士后研究，1995-1997年任华东师范大学生物系副教授，1997-2004年先后在日本大阪市立大学理学部和美国南伊利诺斯州立大学医学院进行访问工作和博士后研究；2004年至2009，在美国贝勒医学院分子生理学和生物物理学系先后从事博士后研究和任Instructor；2010年受聘于华南师范大学生命科学学院，任教授、博导。主持国家自然科学基金、广东省自然科学基金、广东省教育厅引智专项及广东省教育厅研究生示范课程等项目，曾参与多项美国NIH研究项目，在Cell、Cell Research、Nature Communications、eLife、Molecular Neurodegeneration、 Brain, Behavior, and Immunity、Journal of Neuroscince和Chinese Science Bulletin（科学通报）等国内外学术期刊发表百余篇学术论文。参与The Neuroscience of Depression: Features, Diagnosis and Treatment (first edition)撰写和翻译Biopsychology (ninth edition)《生物心理学》。

    兼任华南师范大学-番禺区中心医院基础与转化医学联合实验室副主任，生命科学学院学术委员会委员（第一、二届），广东省神经科学学会副理事长（第六届），广东省生物物理学学会常务理事（第八届），广东省本科高校生物医学工程专业教学指导委员会委员（第一、二届），华南师范大学侨联主席（第八届）、副主席（第九届），广东省侨联（第九、十、十一届）委员，广州欧美同学会（广州留学人员联谊会）理事（第六届）、广东留学人员联谊会●广东欧美同学会常务理事（第一届）。曾任华南师范大学学术委员会（第六、七届）委员。


教育经历
1994年在华南师范大学生物系获博士学位
研究方向
研究方向 1. 焦虑、抑郁及应激的脑机制及干预 2. 神经退变性疾病（突触和神经环路调控） 3. 神经信号转导 研究技术 电生理学（膜片钳、在体细胞内记录、在体细胞外记录、在体多通道记录）、化学遗传学、光遗传学、免疫组织/细胞化学、分子和细胞生物学、行为学等。
讲授课程
“现代神经生物学/生理学进展”、“高级神经生理学/生理学”、“神经生物学/生理学实验技术” 、“细胞的跨膜信号转导”、“分子细胞生物学”、“离子通道学”，博士生、硕士生必修课。 “人体及动物生理学”、“人体解剖生理学”、“神经生理学”、“细胞膜离子通道”和“大脑的奥秘”，本科生必修课、选修课或通识课。
承担课题
1. 国家自然科学基金面上项目，“小清蛋白神经元去泛素化酶CYLD在调控海马依赖性场景恐惧记忆中的作用与机制”（批准号32371065），2024.01.01-2027.12.31。 2. 国家自然科学基金面上项目，“去泛素化酶CYLD导致小鼠焦虑样行为的机理研究”（批准号3187070154），2019.01-2022.12。 3. 广东省自然科学基金面上项目，“去泛素化酶CYLD调控纹状体中型多棘神经元形态与功能的机制”（批准号2023A1515010899），2023.01-2025.12。 4. 广东省自然科学基金面上项目，“背侧纹状体去泛素化酶CYLD对小鼠焦虑行为的作用及机制（批准号2021A1515010804）”，2021.01-2023.12。 5. 广东省教育厅研究生教育创新计划示范课程项目，“神经生物学进展”（批准号2022SFKC_034）。 6. 广东省重点领域研发计划2018‐2019 年度“脑科学与类脑研究”专题二“脑疾病治疗关键技术研究之脑内原位神经再生技术研发”（批准号201813030332001），2019.01-2022.12。
论文专著

神经精神疾病相关研究代表论文：

1.       Jiang J, Tan S, Feng X, Peng Y, Long C*, Yang L*. (2023) Distinct ACC neural mechanisms underlie authentic and transmitted anxiety induced by maternal separation in mice. Journal of Neuroscience. Oct 16:JN-RM-0558-23. doi: 10.1523/JNEUROSCI.0558-23.2023. Online ahead of print.  IF=5.3/Q1.

2.       Tan SY, Jiang JX, Huang HX, Mo XP, Feng JR, Chen Y, Yang L*, Long C*. (2023) Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum. Frontiers in Molecular Neuroscience. 16: 1107355.  IF=4.8/Q1.

3.       Jiang J#, Tang B#, Wang L#, Huo Q#, Tan S#, Misrani A, Han Y, Li H, Hu H, Wang J, Cheng T, Tabassum S, Chen M, Xie W, Long C*, Yang L*. (2022) Systemic LPS-induced microglial activation results in increased GABAergic tone: a mechanism of protection against neuroinflammation in the medial prefrontal cortex in mice. Brain, Behavior, and Immunity. 99: 53-69.  IF=15.1/Q1.

4.       Li HD, Li DN, Yang L, Long C*. (2021) Deficiency of CYLD impairs fear memory of mice and disrupts neuronal activity and synaptic transmission in the basolateral amygdala. Frontiers in Cellular Neuroscience. 15: 740175.  IF2021-2022=5.3/Q1.

5.       Han YY, Jin K, Pan QS, Li B, Wu ZQ, Gan L, Yang L*, Long C*. (2020) Microglial activation in the dorsal striatum participates in anxiety-like behavior in Cyld knockout mice. Brain, Behavior, and Immunity. 89: 326-338.  IF=15.1/Q1.

钙信号转导相关研究代表论文：

6. Durham WJ#, Aracena-Parks P#, Long C#, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman1 CP, Baker M, Shirokova N, Protasi F, Dirksen R, Hamilton SL*. (2008) RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knock-in mice. Cell. 133: 53-65. 

7. Long C, Cook LG, Wu GY, Mitchell BM*. (2007) Removal of FKBP12/12.6 from endothelial ryanodine receptors leads to an intracellular calcium leak and endothelial dysfunction. Arteriosclerosis, Thrombosis and Vascular Biology. 27: 1580-1586. 

8. Long C, Cook LG, Hamilton SL, Wu GY, Mitchell BM. (2007) FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure. Hypertension. 49: 569-576. 

光信号转导相关研究代表论文：

9. Long C, Iino M. (2001) Light-dependent osmoregulation in pea stem protoplasts. photoreceptors, tissue specificity, ion relationships, and physiological implications. Plant Physiology. 125(4): 1854-1869. 

10. Long C*, Wang XJ, Pan RC. (1998) The effect of external Ca2+ and Ca2+-channel modulators on red-light-induced swelling of protoplasts of Phaseolus radiatus L. Cell Research. 8(1): 41-50. 

11. Long C*, Wang XJ, Pan RC. (1995) The role of calcium ions in red light-induced swelling of mung bean protoplasts. Chinese Science Bulletin (科学通报). 40(3): 248-251.

其它主要论文：

12. Misrani A#, Tabassum S#, Wang T#, Huang H, Jiang J, Diao H, Zhao Y, Huang Z, Tan S, Long C*, Yang L*. (2024) Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex. Neural Regeneration Research. 19(6): 1351-1359. IF=6.1/Q1.

13. Misrani A#, Tabassum S#, Zhang ZY, Tan SH, Long C*. (2023) Urolithin A prevents sleep-deprivation-induced neuroinflammation and mitochondrial dysfunction in young and aged mice. Molecular Neurobiology. doi: 10.1007/s12035-023-03651-x.  IF=5.3/Q1.

14. Tabassum S#, Misrani A#, Huang HX, Zhang ZY, Li QW, Long C*. (2023) Resveratrol attenuates chronic unpredictable mild stress-induced alterations in the SIRT1/PGC1α/SIRT3 pathway and associated mitochondrial dysfunction in mice. Molecular Neurobiology. 60(9): 5102-5116.  IF=5.3/Q1.

15. Li Y, Wang JZ, Deng YM, Wang K, Yang L*, Long C*. (2023) Amyloid-β Protein Precursor Regulates Electrophysiological Properties in the Hippocampus via Altered Kv1.4 Expression and Function in Mice. Journal of Alzheimer's Disease. 92(4): 1241-1256.  IF=4.0/Q2.

16. Chen SY, Liu KF, Tan SY, Chen XS, Li HD, Li JJ, Zhou JW, Yang L*, Long C*. Deubiquitinase CYLD regulates excitatory synaptic transmission and short-term plasticity in the hippocampus. Brain Research. 2023; 1806: 148313.  IF= 2.9/Q3.

17. Tan S, Mo X, Qin H, Dong B, Zhou J, Long C, Yang L*. (2023) Biocytin-labeling in whole-cell recording: Electrophysiological and morphological properties of pyramidal neurons in CYLD-deficient mice. Molecules. 28(10): 4092.  IF= 4.6/Q2.

18. Han YY, Zhou JW, Guo ZW, Wu ZQ, Zhang ZY, Liu DX*, Long C*. Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice. Stress. 2023; 26(1): 2228925. IF=2.3/Q3.

19. Ghouse M#, Li M#, Long C*, Jiang JX*. (2023) Multichannel extracellular recording in freely moving mice. Journal of Visualized Experiments (JoVE). 195: e65245.  IF=1.2/Q3.

20. Li C, Yu P, Wang Z, Long C, Xiao C, Xing J, Dong B, Zhai J, Zhou L, Zhou Z, Wang Y, Zhu W, Tan G, Ning C, Zhou Y, Mao C. (2023) Electro-mechanical coupling directs endothelial activities through intracellular calcium ion deployment. Materials Horizons. 10(11): 4903-4913.  IF=13.3/Q1.

21. 张梦倩，储智勇，钱晓明，王梓涵，刘德祥，龙程*。(2023) 河鲀毒素——一种具有缓解癌性疼痛潜力的药物。生物化学与生物物理学进展。50(7): 1584-1596。SCI收录.

22. Tabassum S#, Misrani A#, Huo Q#, Ahmed A, Long C*, Yang L*. (2022) Minocycline ameliorates chronic unpredictable mild stress-induced neuroinflammation and abnormal mPFC-HIPP oscillations in mice. Molecular Neurobiology 59(11): 6874-6895.  IF2021-2022=5.682/Q1.

23. Zhang Z, Luo W, Han Y, Misrani A, Chen H, Long C. (2022) Effect of microRNA-455-5p (miR-455-5p) on the expression of the cytokine signaling-3 (SOCS3) gene during myocardial infarction. Journal of Biomedical Nanotechnology. 18(1): 202-210.  IF2021-2022=3.641/Q3.

24. Liu Y#, Zhao Y#, Min Y, Guo K, Chen Y, Huang Z*, Long C*. (2022) Effects and mechanisms of bone marrow mesenchymal stem cell transplantation for treatment of ischemic stroke in hypertensive rats. International Journal of Stem Cells. 15(2): 217-226.  IF2021-2022=3.011/Q4.

25. Chen B#, Misrani A#, Long C, He Z*, Chen K*, Yang L*. (2022) Pigment of Ceiba speciosa (A. St.-Hil.) flowers: separation, extraction, purification and antioxidant activity. Molecules. 27: 3555. IF2021-2022=4.927/Q2.

26. Shen J#, Li M#, Long C, Yang L*, Jiang J*. (2022) Altered odor-evoked electrophysiological responses in the anterior piriform cortex of conscious APP/PS1 mice. Journal of Alzheimer's Disease. 90(3): 1277-1289.  IF2021-2022=4.160/Q2.

27. Zhang Z, Li J, Long C, Han Y, Fan J, Misrani A, Ji X. (2022) Regulatory mechanism of circEIF4G2 targeting miR-26a in acute myocardial infarction. Journal of Healthcare Engineering. 2022: 5308372. IF2021-2022=3.822/Q2.

28. Wang H, Chiang C, Xue C, Zhou L, Li S, Zhou Y, Zhang Z, Xie M, Xiao T, Hu H, Zhu L, Long C, Zou Y, Wang T, Zheng D*. Dezocine induces apoptosis in human cervical carcinoma Hela cells via the endoplasmic reticulum stress pathway. Toxicology Research. 2022; 11(3): 498-510.  IF2021-2022=2.680/Q3.

29. Chen M#, Chen Y#, Huo Q#, Wang L, Tan S, Misrani A, Jiang J, Chen J, Chen S, Zhang J, Tabassum S, Wang J, Chen X, Long C, Yang L*. (2021) Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models. Molecular Neurodegeneration. 16(1): 14. IF2021-2022=18.879/Q1.

30. Peng YG, Cai PJ, Hu JH, Jiang JX*; Zhang JJ, Yang L*, Long C*. (2021) Altered corticostriatal synchronization associated with compulsive-like behavior in APP/PS1 mice. Experimental Neurology. 344: 113805. IF2021-2022=5.620/Q2.

31. Misrani A, Long C*. (2021) Chapter 33: Citalopram and usage in sleep-deprivation-induced depression. The Neuroscience of Depression: Features, Diagnosis and Treatment. Editors: Martin C, Hunter LA, Patel V, Preedy V, Rajendram R. Elsevier, 1st Edition, pp 337-344 of 1166.

32. Huo Q#, Tabassum S#, Chen M, Sun M, Deng Y, Zheng X, Chen J, Long C*, Yang L*. (2021) APP deficiency changes neuronal electrical activity and levels of mitochondrial proteins in the medical prefrontal cortex. Journal of Alzheimer's Disease. 81(4): 1469-1482.  IF2021-2022=4.16/Q2.

33. Ahmed A#, Misrani A#, Tabbasum S, Yang L, Long C*. (2021) Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus. Brain Research Bulletin. 174: 41-52.  IF2021-2022=3.715/Q2.

34. Tabassum S#, Misrani A#, Tabassum S, Ahmed A, Yang L*, Long C*. (2021) Disrupted prefrontal neuronal oscillations and morphology induced by sleep deprivation in young APP/PS1 transgenic AD mice. Brain Research Bulletin. 166: 12-20.  IF2021-2022=3.715/Q2.

35. Feng XY#, Hu HD#, Chen J, Long C, Yang L*, Wang L*. (2021) Acute neuroinflammation increases excitability of prefrontal parvalbumin interneurons and their functional recruitment during novel object recognition. Brain, Behavior, and Immunity. 98: 48–58. IF2021-2022=19.227/Q1.

36. Qi Z, Wang T, Chen X, Wong CK, Ding Q, Sauer H, Chen ZF, Long C, Yao X, Cai Z, Tsang SY*. (2021) Extracellular and intracellular angiotensin II regulate the automaticity of developing cardiomyocytes via different signaling pathways. Frontiers in Molecular Biosciences. 8: 699827. IF2021-2022=6.113/Q1.

37. Yu W#, Wu X#, Chen Y#, Liang Z#, Jiang J, Misrani A, Su Y, Peng Y, Chen J, Tang B, Sun M, Long C, Shen J*, Yang L*. Pelvic pain alters functional connectivity between anterior cingulate cortex and hippocampus in both humans and a rat model. Frontiers in Systems Neuroscience. 2021; 15: 642349. IF2021-2022=3.785/Q3.

38. 李惠冬、储智勇、钱晓明、龙程*。（2021）反毒为药：精准控制河豚毒素用作局部麻醉药的新进展。生物化学与生物物理学进展。48（9）：1031~1041。

39. Misrani A#, Tabassum S#, Wang M, Chen J, Yang L, Long C*. (2020) Citalopram prevents sleep-deprivation-induced reduction in CaMKII-CREBBDNF signaling in mouse prefrontal cortex. Brain Research Bulletin. 155: 11-18. IF2020-2021=4.077/Q2.

40. Zhang JW#, Tabassum S#, Jiang JX, Long C*. Optimized Golgi-Cox staining validated in the hippocampus of spared nerve injury mouse model. Frontiers in Neuroanatomy. 2020; 14: 585513. IF2020-2021=3.856/Q2.

41. Chen J, Dong B, Feng X, Jiang D, Chen G, Long C*, Yang L*. (2020) Aberrant mPFC GABAergic synaptic transmission and fear behavior in neuroligin-2 R215H knock-in mice. Brain Research. 1730: 146671. IF2020-2021=3.252/Q3.

42. Misrani A#, Tabassum S#, Chen X, Tan SY, Wang JC, Yang L, Long C*. (2019) Differential effects of citalopram on sleep-deprivation-induceddepressive-like behavior and memory impairments in mice. Progress in Neuro-psychopharmacology & Biological Psychiatry. 88: 102-111.  IF2019-2020=5.067/Q2.

43. Tabassum S#, Misrani A#, Tang BL, Chen J, Yang L*, Long C*. (2019) Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice. Scientific Reports. 9(1): 4512.  IF2018-2019=3.998/Q3.

44. Hu JC, Wang ZJ, Feng XY, Long C*, Schiller D*. (2019) Post-retrieval oxytocin facilitates next day extinction of threat memory in humans. Psychopharmacology. 236(1): 293-301.  IF2018-2019=3.13/Q3.

45. Jiang J, Zheng Y, Chen Y, Zahra A, Long C, Yang L*. (2019) Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice. Brain Research. 1717: 27-34.  IF2019-2020=2.733/Q3.

46. Wu Z#, Huo Q#, Ren L, Dong F, Feng M, Wang Y, Bai Y, Lüscher B, Li ST, Wang GL, Long C, Wang Y, Wu G, Chen G*. (2019) Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels. Molecular Brain. 2019; 12(1): 50.  IF2019-2020=4.686/Q2.

47. Lou WPK#, Wang L#, Long C, Liu L*, Fei JF*. (2019) Direct gene knock-out of axolotl spinal cord neural stem cells via electroporation of CAS9 protein-gRNA complexes. Journal of Visualized Experiments (JoVE). 125: e59850.  IF2019-2020=1.163/Q3.

48. Zhang Z, Long C, Li X, Xie Q, Song M, Zhang Y. (2019) CEACAM-1 promotes myocardial injury following coxsackievirus infection by regulating the coxsackievirus-adenovirus receptor. Medicine. 98(19): e15629.  IF2018-2019=1.87/Q4.

49. Zhang JJ#, Hao CY#, Jiang JX#, Feng YJ, Chen X, Zheng Y, Liu JW, Zhang ZL, Long C, Yang L*. (2018) The mechanisms underlying olfactory deficits in apolipoprotein E-deficient mice: focuson olfactory epithelium and olfactory bulb. Neurobiology of Aging. 62: 20-33.  IF2018-2019=4.398/Q2. 

50. Wang JZ#, Long C#*, Li KY, Xu HT, Yuan LL, Wu GY*. (2018) Potent block of potassium channels by MEK inhibitor U0126 in primary cultures and brain slices. Scientific Reports. 8(1): 8808. IF2018-2019=4.011/Q3.

51. Zahra A, Jiang J, Chen Y, Long C, Yang L*. (2018) Memantine rescues prenatal citalopram exposure-induced striatal and social abnormalities in mice. Experimental Neurology. 307: 145-154.  IF2018-2019=4.562/Q2.

52. Yu WJ, Guan F, Fu l, Long C, Yang L*. (2018) Disrupted physical pain sensation by social exclusion in women with dysmenorrhea. Journal of Pain Research. 11: 1469-1477.  IF2018-2019=2.236/Q3.

53. Zhang G, Zhang T, Wu L, Zhou X, Gu J, Li C, Liu W, Long C, Yang X, Shan L, Xu L, Wang Y, Sun Y, Zhang Z. (2018) Neuroprotective effect and mechanism of action of tetramethylpyrazine nitrone for ischemic stroke therapy. Neuromolecular Medicine. 20(1): 97-111.  IF2018-2019=2.576/Q3.

54. Chen M, Wang JZ, Zhang JX, Zheng XZ, Justice NJ, Wang K, Li Y, Huo QW, Zhang JJ, Li HM, Wang Y, Lu NN, Zheng H, Long C, Yang L*. (2017) APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. eLife. 6: e20142.  IF2017-2018=7.616/Q1.

55. Huo QW#, Chen M#, He QS, Zhang JJ, Li B, Jin K, Long C*, Yang L*. (2017) Prefrontal cortical GABAergic dysfunction contributes to aberrant UP-state duration in APP knockout mice. Cerebral Cortex. 27(8): 4060-4072.  IF2017-2018=6.308/Q1.

56. Huo QW#, Tabassum S#, Misrani A, Long C*. (2017) Recording EEG in freely moving neonatal rats with a novel method. Journal of Visualized Experiments (JoVE). 123: e55489.  IF2017-2018=1.184/Q3.

57. Misrani A, Tabassum S, Long C*. (2017) Oxytocin system in neuropsychiatric disorders: Old concept, new insights. Acta Physiologica Sinica. 69(2): 196–206.

58. Cai ZL#, Zhang JJ#, Chen M, Wang JZ, Xiao P, Yang L*, Long C*. (2016) Both pre- and post-synaptic defects contribute to aberrant cholinergic transmission in superior cervical ganglia of APP-/- mice. Neuropharmacology. 110 (Pt A): 493-502.  IF2016-2017=5.012/Q2.

59. Zhang J#, Chen M#, Li B, Lv BH, Jin K, Zheng SD, Yang L*, Long C*. (2016) Altered striatal rhythmic activity in cylindromatosis knock-out mice due to enhanced GABAergic inhibition. Neuropharmacology. 100(Pt A): 260-267.  IF2016-2017=5.012/Q2.

60. Qi ZH, Wong CK, Suen CH, Wang JZ, Long C, Sauer H, Yao XQ, Tsang SY*. (2016) TRPC3 regulates the automaticity of embryonic stem 2 cell-derived cardiomyocytes. International Journal of Cardiology. 203: 169-181.  IF2016-2017=6.189/Q2.

61. Li M, Long C, Yang L*. (2015) Hippocampal-prefrontal circuit and disrupted functional connectivity between the two structures in neuronal disorders. BioMed Research International. 2015: 810548. IF2015-2016=2.134/Q3.

62. Chen HY, Xu DP, Tan GL, Cai W, Zhang GX, Cui W, Wang JZ, Long C, Sun YW, Yu P, Tsim KW, Zhang ZJ, Han YF, Wang YQ*. (2015) A potent multi-functional neuroprotective derivative of tetramethylpyrazine. Journal of Molecular Neuroscience. 56(4): 977-987.  IF2015-2016=2.352/Q3.


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