生命科学学院

School of Life Sciences

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王璋

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  • 性别:男
  • 职称:研究员
  • 学历:博士
  • 学科:微生物学
个人简历

2009年毕业于武汉大学获生物学学士学位,2014年于美国弗吉尼亚大学获得微生物学博士学位;2014年至2018年就职于美国葛兰素史克(GlaxoSmithKline)计算生物学部门任博士后和高级研究员。201810月作为华南师范大学青年拔尖人才引进到华南师范大学生命科学学院,从事人体微生物组学研究。2019年获广东省青年珠江学者,现任广东省精准医学应用学会精准健康管理分会常务委员,广东省慢阻肺康复工程技术研究中心委员会委员等。

从事人体微生物组学研究,在American Journal of Respiratory and Critical Care MedicineEuropean Respiratory JournalThoraxMolecular Biology and EvolutionISME JournalNature等国际期刊上发表论文20余篇。相关工作得到了ScienceNature Reviews MicrobiologyLancetNature Genetics等期刊他人千余次引用,得到期刊Editorial报道,F1000以及著名科学媒体Science DailyScientific AmericanBBC等专题报道。主持国家自然科学基金面上项目等国家及省部级项目多项,作为主要完成人参与英国MRC和美国NSF资助重大项目。担任Molecular Biology and EvolutionmSystems等期刊审稿人。


教育经历
2009年毕业于武汉大学获生物学学士学位, 2014年于美国弗吉尼亚大学获得微生物学博士学位
研究方向
(1)呼吸系统疾病微生物组学:大量研究证据表明人体呼吸道微生物菌群对慢性呼吸道疾病有着重要影响。但气道菌群在慢阻肺中的具体功能以及与宿主免疫系统的互作机制尚不明确。我们前期对大量慢阻肺患者的气道菌群动态进行了详细观测,首次深入揭示慢阻肺患者气道微生态特征。研究成果发表于呼吸医学权威杂志AJRCCM(IF:17.45),ERJ(IF:12.24,ESI高被引论文),Thorax(IF: 10.84),ISME Journal(IF: 9.18)等,并受到杂志主编专栏综述报道。我们已同广州市多家三甲医院合作,进一步应用多组学技术,结合体内外细胞动物功能实验,揭示慢性呼吸系统疾病气道菌群宿主互作机制。 (2)多组学数据整合与应用:人体微生物组学的研究进入到了多组学的时代,来自全球各地研究机构的海量大数据的产出,为我们深入探究生命组学与疾病的内在关联带来了新的机遇和挑战。本团队针对人体微生物组、转录组等多组学公共数据库进行系统整理和深度挖掘,建立首例基于不同疾病类型的多组学公共数据集。我们拟对不同疾病类型的多组学数据进行深度挖掘,以探索不同疾病类型共有和特有的菌群失调方式、不同疾病类型共有和特有的宿主免疫和炎症途径、不同疾病类型菌群失调与炎症反应的内在关联。 (3)线粒体起源与生命演化:线粒体的起源在生命进化的历史中具有开创性的意义。当前的研究普遍认为,线粒体起源于独立的内共生细菌(内共生理论)。然而,线粒体的祖先在进化树上确切的位置仍饱受争议。在前期研究中,通过系统发育基因组学(Phylogenomics)手段,我们实现了对线粒体起源的精准定位和线粒体祖先基因组的重建,相关研究成果发表于Molecular Biology and Evolution, ISME Journal等杂志。我们拟通过系统发育基因组学、比较基因组学、宏基因组学等一系列手段,进一步探究线粒体和真核生物的起源与演化规律。
讲授课程
生物信息学 (研究生必修课程)
承担课题
国家自然基金面上项目(2020-2024),《多组学技术联合解析慢阻肺急性加重气道微生物组宿主互作机制》,62万元 教育部极端环境医学重点实验室开放性课题(2020-2022),《气道微生态失衡与高原肺水肿病原学机制研究》,15万元 广东省自然科学基金面上项目(2020-2022),《基于宏基因组和代谢组学对慢阻肺“气道菌群-宿主炎症”互作机制研究》,10万元
论文专著

论文专著(#第一作者,*通讯作者)

按照以下格式,按照时间倒序列出,论文中所有作者都要列出。

1.      Liu H1, Liang Z1, Cao N1, Yi X1, Tan X, Liu Z, Wang F, Yang Y, Li C, Xiang Z, He Y, Su J, Wang Z#, Chen R#, Zhou H#. Airway bacterial and fungal microbiome in chronic obstructive pulmonary disease.  Medicine in Microecology. 2021 Apr 16. P100335.

2.      Wang Z#, Locantore N, Haldar K, Ramsheh MY, Beech AS, Ma W, Brown JR, Tal-Singer R, Barer MR, Bafadhel M, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Miller BE, Brightling CE. Inflammatory Endotype Associated Airway Microbiome in COPD Clinical Stability and Exacerbations – A Multi-Cohort Longitudinal Analysis. Am J Respir Crit Care Med. 2020 Dec 17. doi: 10.1164/rccm.202009-3448OC (IF: 17.45期刊专题报道)

3.      Tian T, Shu B, Jiang Y, Ye M, Liu L, Guo Z, Han Z, Wang Z, Zhou X. An Ultralocalized Cas13a Assay Enables Universal and Nucleic Acid Amplification-Free Single-Molecule RNA Diagnostics. ACS Nano. 2020 Dec 17. https://doi.org/10.1021/acsnano.0c08165 (IF: 14.59)

4.      Wang Z1#, Yang Y1, Yan Z1, Liu H, Chen B, Liang Z, Wang F, Miller BE, Tal-Singer R, Yi X, Li J, Stampfli MR, Zhou H, Brightling CE, Brown JR, Wu M, Chen R, Shu W. Multi-omic meta-analysis identifies functional signatures of airway microbiome in chronic obstructive pulmonary disease. ISME Journal. 2020 Nov;14(11):2748-2765 (IF: 9.18F1000 Prime推荐)

5.      Liu H1, Zheng D1, Lin Y, Liu Z, Liang Z, Su J, Chen R, Zhou H#, Wang Z#. Association of sputum microbiome with clinical outcome of initial antibiotic treatment in hospitalized patients with acute exacerbations of COPD. Pharmacological Research. 2020 Jul 28. 160 (2020) 105095. (IF: 5.89)

6.      Wang Z1, Liu H1, Wang F1, Yang Y1, Wang X, Chen B, Stampfli MR, Zhou H, Shu W, Brightling CE, Liang Z, Chen R. A refined view of airway microbiome in chronic obstructive pulmonary disease at species and strain-levels. Frontiers in Microbiology. 2020 Jul 30. doi: 10.3389/fmicb.2020.01758. (IF: 4.24)

7.      Beech AS, Lea S, Kolsum U, Wang Z, Miller BE, Donaldson GC, Wedzicha JA, Brightling CE, Singh D. Bacteria and sputum inflammatory cell count; a COPD cohort analysis. Respir Res. 2020 Nov 1;21(1):289. (IF: 3.92)

8.      Haldar K1, George L1, Wang Z, Mistry V, Ramsheh MY, Free RC, John C, Reeves NF, Miller BE, Tal-Singer R, Webb AJ, Brookes AJ, Tobin MD, Singh D, Donaldson GC, Wedzicha JA, Brown JR, Barer MR, Brightling CE. The sputum microbiome is distinct between COPD and health, independent of smoking history. Respiratory Research. 2020 Jul 14;21(1):183. (IF: 3.92)

9.      Wang Z1, Wu J1, Li D, Tang X, Zhao Y, Cai X, Chen X, Chen X, Huang Q, Huang R. Traditional Chinese medicine Biqi capsule compared with leflunomide in combination with methotrexate in patients with rheumatoid arthritis: a randomized controlled trial. Chin Med. 2020 Apr 23. 15:36. (IF: 2.96)

10.  Yuan C, Tian T, Sun J, Hu M, Wang X, Xiong E, Cheng M, Bao Y, Lin W, Jiang J, Yang C, Chen Q, Zhang H, Wang H, Wang X, Deng X, Liao X, Liu YH, Wang Z#, Zhang G#, Zhou X#. Universal and Naked-Eye Gene Detection Platform Based on CRISPR/Cas12a/13a System. Anal Chem. 2020 Feb 7. doi: 10.1021/acs.analchem.9b0559 (IF: 6.79)

11.  Nixon CC, Mavigner M, Sampey GC, Brooks DA, Spagnuolo RA, Irlbeck DM, Mattingly C, Ho PT, Schoof N, Cammon CG, Tharp GK, Kanke M, Wang Z, Cleary RA, Upadhyay AA, De C, Wills SR, Falcinelli SD, Galardi C, Walum H, Schramm NJ, Deutsch J, Lifson JD, Fennessey CM, Keele BF, Jean S, Maguire S, Liao B, Browne EP, Ferris RG, Brehm JH, Favre D, Vanderford TH, Bosinger SE, Jones CD, Routy J, Archin NM, Margolis DM, Wahl A, Dunham RM, Silvestri G, Chahroudi A, Garcia JV. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. 2020. Nature 578(7793):160-165. (IF: 43.07)

12.  Washburn ML, Wang Z, Walton AH, Geodegebuure SP, Figueroa DJ, Van Horn S, Grossman J, Remlinger K, Madsen H, Brown JR, Srinivasan R, Wolf A, Yi V, Hawkins WG, Field RC, Hotchkiss RS. CD4 and CD8 T-cell and monocyte specific RNA-Seq analysis in septic and non-septic critically-ill patients and in patients with cancer. 2019. Journal of Immunology 203(7):1897-1908 (IF: 4.72).

13.  Wang Z, Maschera B, Lea S, Kolsum U, Michalovich D, Van Horn S, Traini C, Brown JR, Hessel EM, Singh D, 2018. Airway host-microbiome interactions in chronic obstructive pulmonary diseases. 2019. Respiratory Research 20(1):113 (IF: 3.92)

14.  Wang Z1, Arat S1, Magid-Slav M, Brown JR. 2018. Meta-analysis of human gene expression in response to Mycobacterium tuberculosis infection reveals potential therapeutic targets. BMC Systems Biology 12(1):3. doi: 10.1186/s12918-017-0524-z (IF: 2.05)

15.  Wang Z, Saha S, Van Horn S, Thomas E, Traini C, Sathe G, Rajpal DK, Brown JR. 2017. Gut microbiome differences between metformin and liraglutide treated T2DM subjects. Endocrinology, Diabetes & Metabolism 10.1002/edm2.9.

16.  Wang Z1, Singh R1, Miller BE, Tal-Singer R, Van Horn S, Tomsho L, Mackay A, Allinson JP, Webb AJ, Brookes AJ, George LM, Barker B, Kolsum U, Donnelly LE, Belchamber K, Barnes PJ, Singh D, Brightling CE, Donaldson GC, Wedzicha JA, Brown JR on behalf of COPDMAP. 2018. Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study. Thorax Apr;73(4):331-338 (IF: 10.84)

17.  Wang Z, Wu M. 2017. Comparative genomic analysis on Acanthamoeba endosymbionts highlights the role of amoebae as a melting pot shaping the Rickettsiales evolution. Genome Biology and Evolution 9:3214-3224. (IF: 3.94)

18.  Cichewicz K, Garren EJ, Adiele C, Aso Y, Wang Z, Wu M, Birman S, Rubin GM, Hirsh J. 2016. A New Brain Dopamine Deficient Drosophila and its Pharmacological and Genetic Rescue. Genes Brain Behav. doi: 10.1111/gbb.12353. (IF: 3.50)

19.  Wang Z1, Bafadhel M1, Haldar K, Spivak A, Mayhew D, Miller BE, Tal-Singer R, Johnston SL, Ramsheh MY, Barer MR, Brightling CE, Brown JR. 2016. Lung microbiome dynamics in chronic obstructive pulmonary disease exacerbations. Eur Respir J. Apr;47(4):1082-92. (IF: 12.34,ESI高被引论文,期刊专题报道)

20.  Wang Z, Wu M. 2015. An integrated phylogenomic approach toward pinpointing the origin of mitochondria. Scientific Reports doi:10.1038/srep07949. (IF: 4.00)

21.  Wang Z, Wu M. 2014. Phylogenomic reconstruction indicates mitochondrial ancestor was an energy parasite. PLoS ONE 9(10): e110685. (IF: 2.74)

22.  Wang Z, Wu M. 2014. Complete genome sequence of the endosymbiont of Acanthamoeba strain UWC8, an amoeba endosymbiont belonging to the “Candidatus Midichloriaceae” family in Rickettsiales. Genome Announc. 2(4):e00791-14.

23.  Kopac S1, Wang Z1, Wiedenbeck J, Sherry J, Wu M, Cohan FM. 2014. Genomic heterogeneity and ecological speciation within one subspecies of Bacillus subtilis. Appl. Environ. Microbiol. 80(16):4842-53. (IF: 4.02)

24.  Lin W1, Deng A1, Wang Z, Li Y, Wen T, Wu L, Wu M, Pan Y. 2014. Genomic insights into the uncultured genus “Candidatus Magnetobacterium” in the phylum Nitrospirae. ISME Journal. doi: 10.1038/ismej.2014.94. (IF: 9.18)

25.  Wang Z, Wu M. 2013. A phylum-level bacterial phylogenetic marker database. Mol Biol Evol. 30(6):1258-62. (IF: 11.06)

26.  Wang Z, Kadouri DE, Wu M. 2011. Genomic insights into an obligate epibiotic bacterial predator: Micavibrio aeruginosavorus ARL-13. BMC Genomics 12:453. (IF: 3.59)

27.  Luo X, Wang Z, Dai J, Zhang L, Fang C. 2010. Cohnella damensis sp. nov., a motile xylanolytic bacteria isolated from a low altitude area in Tibet. J Microbiol Biotechnol 20:410-414. (IF: 1.65)

28.  Luo X, Wang Z, Dai J, Zhang L, Li J, Tang Y, Wang Y, Fang C. 2010. Pedobacter glucosidilyticus sp. nov., isolated from dry riverbed soil. Int J Syst Evol Microbiol 60:229-233.