生命科学学院

School of Life Sciences

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张钟徽

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  • 性别:男
  • 职称:研究员
  • 学历:博士研究生
  • 学科:植物学
个人简历

张钟徽,博士,研究员,博士生导师。2003年中山大学生物科学专业理学学士,2009年于中山大学获得植物学博士学位,其中2004 - 2009年在中国科学院遗传与发育生物学研究所客座学习和研究。2009 - 2011年继续在中科院遗传发育所工作,2011 - 2016年在美国德州农工大学(Texas A&M University)进行博士后研究,2017年作为海外高层次青年拔尖人才引进并入职华南师范大学生命科学学院。2020年入选广东省“珠江人才计划”。现主持承担国家自然科学基金面上项目、广东省自然科学杰出青年基金项目。近年来主要从事植物发育与逆境胁迫响应相关的表观遗传调控机理研究,在eLifeNature PlantsPlant CellPNASCurrent Opinion in Plant Biology等国际权威期刊上发表SCI论文19篇;获得2013年教育部自然科学奖一等奖和2014年国家自然科学奖二等奖。现任广东省植物生理学会理事、广东省遗传学会理事、植物生理学报编委以及DevelopmentPLoS PathogenMolecular Plant PathologySCI期刊审稿人。


教育经历
2003年中山大学生物科学专业理学学士 2009年于中山大学获得植物学博士学位
工作经历
2004 - 2009年在中国科学院遗传与发育生物学研究所客座学习和研究。 2009 - 2011年继续在中科院遗传发育所工作, 2011 - 2016年在美国德州农工大学(Texas A&M University)进行博士后研究, 2017年作为海外高层次青年拔尖人才引进并入职华南师范大学生命科学学院。
研究方向
(1) 植物miRNA生物合成与代谢的调控机理; 植物细胞内miRNA生物合成的调控是一个多层面的精细过程,例如转录、转录后剪接、pri-miRNA的剪切、miRNA的成熟、RNA的稳定性、主要生物合成元件蛋白的稳定性、miRNA的时空分布等多个环节都可能影响miRNA的含量及其对下游靶基因的调控。本实验室主要通过遗传学、生物信息学、细胞生物学、生物化学和分子生物学等方面的技术手段,找寻参与miRNA途径的新调控因子,深入阐释miRNA合成与代谢过程的调控机理。 (2) 植物逆境胁迫响应的表观遗传学调控 植物在生长发育过程中常常会遭遇各种生物和非生物逆境胁迫等不利因素的影响,固着生长的植物不能主动趋避,只能依靠自身一些胁迫响应机制来实现防御,表观遗传调控在其中起到了非常重要的作用。本实验室重点关注并致力于解析表观遗传修饰相关基因在逆境胁迫响应过程中的功能和调控机理,挖掘与植物逆境胁迫应答相关的表观遗传调控因子,最终为现代分子育种技术选育农作物抗逆新品种提供新思路。
讲授课程
《高级植物生物学》,研究生,必修课 《生物信息学》,研究生,选修课 《生物信息学》,本科生,必修/选修课 《遗传学实验》,本科生,必修课
承担课题
国家自然基金面上项目(2018-2021),60万 广东省自然科学杰出青年基金(2019-2023),100万
论文专著

论文专著(#第一作者,*通讯作者):

Feng Xiong#, Cun-Ying Duan, Hai-Hong Liu, Ju-Hua Wu, Zhong-Hui Zhang, Sha Li, Yan Zhang*. Arabidopsis KETCH1 Is Critical for the Nuclear Accumulation of Ribosomal Proteins and Gametogenesis. 2020, Plant Cell. 32 (4), 1270-1284.

Zhonghui Zhang#, Fuqu Hu#, Min Woo Sung, Chang Shu, Claudia Castillo-González, Hisashi Koiwa, Guiliang Tang, Martin Dickman, Pingwei Li*, Xiuren Zhang*. RISC-Interacting Clearing 3’-5’ Exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis. 2017, Elife. e24466

Xinwei Guo#, Zeyang Ma, Zhonghui Zhang, Lailiang Cheng, Xiuren Zhang*, Tianhong Li*. Small RNA-Sequencing Links Physiological Changes and RdDM Process to Vegetative-to-Floral Transition in Apple. 2017, Front. Plant Sci. 8, 873.

Zhonghui Zhang#, Xinwei Guo#, Chunxiao Ge#, Zeyang Ma, Mengqiu Jiang, Tianhong Li, Hisashi Koiwa, Seong Wook Yang, Xiuren Zhang*. KETCH1 Imports HYL1 to Nucleus for miRNA Biogenesis in Arabidopsis. 2017, Proc Natl Acad Sci U S A. 114 (15), 4011-4016.

Zhonghui Zhang#, Xiuying Liu#, Xinwei Guo, Xiu-Jie Wang*, Xiuren Zhang*. Arabidopsis AGO3 predominantly recruits 24-nt small RNAs to regulate epigenetic silencing. 2016, Nature Plants. 2, 16049.

Yuyi Zhou#, Minami Honda, Hongliang Zhu, Zhonghui Zhang, Xinwei Guo, Tianhong Li, Zhaohu Li, Xu Peng, Keiji Nakajima, Liusheng Duan, Xiuren Zhang*. Spatiotemporal sequestration of miR165/166 by Arabidopsis Argonaute10 promotes shoot apical meristem maintenance.  2015, Cell Rep. 10(11), 1819-1827.

Li-Ping Yang#, Yuan-Yuan Fang, Chun-Peng An, Li Dong, Zhong-Hui Zhang, Hao Chen, Qi Xie, Hui-Shan Guo*. C2-mediated decrease in DNA methylation, accumulation of siRNAs, and increase in Expression for genes involved in defense pathways in plants infected with beet severe curly top virus. 2013, Plant J. 73 (6), 910-917.

Zhonghui Zhang#, Xiuren Zhang*. Argonautes compete for miR165/166 to regulate shoot apical meristem development. 2012, Cur Opin Plant Biol, 15 (6), 652-658.

Hua-Jun Wu#, Zhonghui Zhang#, Jun-Yi Wang#, Dong-Ha Oh#, Maheshi Dassanayake#, Binghang Liu#, Quanfei Huang#, Hai-Xi Sun, Ran Xia, Yaorong Wu, and others. Insights into salt tolerance from the genome of Thellungiella salsuginea. 2012, Proc Natl Acad Sci U S A. 109 (30), 12219-12224.

Feng Cui, Lijing Liu, Qingzhen Zhao, Zhonghui Zhang, Qingliang Li, Baoying Lin, Yaorong Wu, Sanyuan Tang, Qi Xie*. Arabidopsis ubiquitin conjugase UBC32 is an ERAD component that functions in brassinosteroid-mediated salt stress tolerance. 2012, Plant Cell. 24 (1), 233-244.

Zhonghui Zhang#, Hao Chen, Xiahe Huang, Ran Xia, Qingzhen Zhao, Jianbin Lai, Kunling Teng, Yin Li, Liming Liang, Quansheng Du, Xueping Zhou, Huishan Guo, Qi Xie*. BSCTV C2 attenuates the degradation of SAMDC1 to suppress DNA methylation-mediated gene silencing in Arabidopsis. 2011, Plant Cell. 23 (1), 273-288.

Kunling Teng#, Hao Chen, Jianbin Lai, Zhonghui Zhang, Yuanyuan Fang, Ran Xia, Xueping Zhou, Huishan Guo, Qi Xie*. Involvement of C4 Protein of Beet Severe Curly Top Virus (Family Geminiviridae) in Virus Movement. 2010, PLoS ONE. 5 (6), e11280.

Hao Chen#, Zhonghui Zhang, Kunling Teng, Jianbin Lai, Yiyue Zhang, Yiliang Huang, Yin Li, Liming Liang, Yiqin Wang, Chengcai Chu, Huishan Guo, Qi Xie*. Up-regulation of LSB1/GDU3 affects geminivirus infection by activating the salicylic acid pathway. 2010, Plant J. 62 (1), 12-23.

Lijing Liu#, Yiyue Zhang, Sanyuan Tang, Qingzhen Zhao, Zhonghui Zhang, Huawei Zhang, Li Dong, Huishan Guo, Qi Xie*. An efficient system to detect protein ubiquitination by agroinfiltration in Nicotiana benthamiana. 2010, Plant J. 61(5), 893-903.

Weiquan Wang#, Yaorong Wu, Yin Li, Jiaying Xie, Zhonghui Zhang, Zhiyong Deng, Yiyue Zhang, Cuiping Yang, Jianbin Lai, Huawei Zhang, Hongyan Bao, Sanyuan Tang, Chengwei Yang, Peng Gao, Guixian Xia, Huishan Guo, Qi Xie*. A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes. 2010, Plant Mol Biol.72 (1-2), 91-99.

Jianbin Lai#, Hao Chen, Kunling Teng, Qingzhen Zhao, Zhonghui Zhang, Yin Li, Liming Liang, Ran Xia, Yaorong Wu, Huishan Guo, Qi Xie*. RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle. 2009, Plant J. 57(5), 905-917.

Nuoyan Zheng#, Jose de Jesus Perez, Zhonghui Zhang, Elvira Dominguez, Juan Antonio Garcia, Qi Xie*. Specific and efficient cleavage of fusion proteins by recombinant plum pox virus NIa protease. 2008, Protein Exp Purif. 57(2), 153-162.

Quan-Sheng Du#, Cheng-Guo Duan#, Zhong-Hui Zhang#, Yuan-Yuan Fang, Rong-Xiang Fang, Qi Xie, Hui-Shan Guo*. DCL4 Targets Cucumber Mosaic Virus Satellite RNA at Novel Secondary Structures.  2007, J Virol. 81 (17), 9142-9151

Zhaoqing Chu#, Hao Chen#, Yiyue Zhang, Zhonghui Zhang, Nouyan Zheng, Bojiao Yin, Hongyan Yan, Lei Zhu, Xiangyu Zhao, Ming Yuan, Xiansheng Zhang, Qi Xie*. Knockout of the AtCESA2 gene affects microtubule orientation and causes abnormal cell expansion in Arabidopsis.  2007, Plant Physiol. 143 (1), 213-224.