生命科学学院

School of Life Sciences

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范瑞芳

  • 性别:女
  • 职称:教授
  • 学历:博士研究生
  • 学科:生态毒理学与环境毒理学
个人简历

华南师范大学生命科学院教授,博士研究生导师,生物工程系主任,生命科学学院党委委员。1995年本科毕业于河南师范大学,2000年硕士毕业于北京理工大学,2007年从中科院广州地球化学所博士毕业,20109-20123月获国家留学基金委资助,赴美国加州公共卫生局(California Department of Public Health)访学一年半。华南师范大学-番禺中心医院基础与转化医学联合实验室客座教授,广东省环境科学学会生态毒理学与环境毒理学分会委员,广东省环境诱变剂协会副理事长,国家自然科学基金、科技部、教育部以及广东省等国家和省级项目评审专家,长期担任Environment International, Environmental Science & Technology, Toxicology等国际知名杂志的审稿人。

长期从事环境持久性有机污染物人群暴露监测、环境污染物毒理及对人体健康的影响机制研究。主持国家和省部级基金10余项,在国内外发表中英文论文90余篇,其中80篇被SCIEI收录,引用合计2000余次,高被引论文一篇,一区文章9篇,H指数为27。曾获得华南师范大学 “科研工作优秀奖(2014)”“优秀教师(20192021年度)”“优秀班主任”等荣誉,培养的多名研究生获得国家奖学金广东省优秀学生(研究生)以及校级优秀硕士论文等奖励和荣誉称号;2019年指导本科生获得15届《挑战杯》广东大学生课外学术科技作品竞赛二等奖 已毕业博士两位,硕士17位。


教育经历
1995年本科毕业于河南师范大学 2000年硕士毕业于北京理工大学 2007年从中科院广州地球化学所博士毕业
研究方向
(1)环境内分泌干扰物污染物的神经毒理效应与机制研究 环境内分泌物的神经毒性效应及其分子机制。 (2)环境有机污染物污染与人体健康的关系 以环境中常见的有机污染物,如多环芳烃、挥发性有机污染物、环境雌激素为研究对象,进行普通以及职业暴露人群的暴露监测,通过环境卫生流行病学研究方法寻找环境污染物暴露与人群健康有害结局之间的关系。
讲授课程
现代仪器分析技术,研究生,必修课 物理化学,本科生,必修课
承担课题
[1] 广东省自然科学基金(2023A1515011080), 2023.01-2025.12,10万元,在研。 [2] 广东省国际及粤港澳人才交流项目(海外名师),2022.09-2024.09,5万元,在研。 [3] 广州市番禺区中心医院科研基金重点基金(2021Z001),2022.01-2024.12,20万元,在研。 [4] 国家自然科学基金重点项目(41731279),2018.01-2022.12,60/323万元,子课题负责人,已结题。 [5] 第二次全国污染普查《城乡居民生活能源消费和生活源VOCs普查技术、报表制度、产排污核算方法与指南》(L-201903-05),环境保护部华南环境科学研究所,10万元,2019年05-09,已结题。 [6] 国家自然科学基金(21777048),2018.01-2021.12,64万元,主持,已结题。 [7] 国家自然科学基金 (21477041),2015.01-2018.12, 87万元,主持,已结题。 [8] 广州市科技计划项目 (201510010107), 2015.06-2018.06,20万,主持,已结题。
论文专著

论文专著(#第一作者,*通讯作者,近5)


(1) Lei Wang, Chengmeng Huang, Leizi Li, Qihua Pang, Congcong Wang, Ruifang Fan*. In Vitro and in Silico Assessment of GPER-dependent Neurocytotoxicity of Emerging Bisphenols. Science of the Total Environment, 2023, 862,160762 (IF2021=10.753,一区).

(2) Zhilin Li, Hongxuan Kuang, Leizi Li, Maorong Wu, Zengquan Liao, Keqin Zeng, Yufeng Ye*, Ruifang Fan. What adverse health effects will environmental heavy metal co-exposure bring us: Based on a biological monitoring study of sanitation workers, Environmental Science and Pollution Research, 2023, DOI:. doi.org/10.1007/s11356-022-24805-9.

(3) Hongxuan Kuang, Yonghong Li, Leizi Li, Shengtao Ma, Taicheng An*, Ruifang Fan*.  Four-year population exposure study: Implications for the effectiveness of e-waste control and biomarkers of e-waste pollution. Science of the Total Environment, 2022, 42156595 (IF2021=10.753,一区).

(4) Congcong Wang, Lei Wang, Chengmeng Huang, Yungang Liu, Qihua Pang, Hongyu Han, Ruifang Fan*. Involvement of NLRP3-/Caspase-1-/GSDMD- dependent pyroptosis attenuates BPA-induced apoptosis of neuroblastoma cells. Biochemical Pharmacology2022, 200, 11542. IF2021=6.1,药学一区)

(5) Xuejing Lv#, Jianhua Tan#, Jianglu Feng, Zhilin Li, Weiran Gong, Dingguo Zhang, Hongxuan Kuang, Ruifang Fan* Relationship of Polycyclic Aromatic Hydrocarbons Exposure with Vascular Damages among Sanitation Workers. Journal of Environmental Science and Health, Part C (Toxicology and Carcinogenesis), 2022, 40(2): 154-171. IF2021=3.781

(6) Hongxuan Kuang, Wenji Zhou, Yingwei Zeng, Da Xu, Wanqi Zhu, Shengjie Lin, Ruifang Fan*. Dose makes poison: Insights into the neurotoxicity of perinatal and juvenile exposure to environmental doses of 16 priority-controlled PAHs. Chemosphere, 2022, 134201. IF2021=8.943

(7) Jiaying He#, Qihua Pang#, Chengmeng Huang, Jiaqi Xie, Jindian Hu, Lei Wang, Congcong Wang, Lingxue Meng, Ruifang Fan*. Environmental Dose of 16 Priority-controlled PAHs Mixture Induces Vascular Endothelial Cells Dysfunction through Oxidative Stress. Toxicology in Vitro, 2022, 79:105296. (IF2021=3.685)

(8) 范瑞芳,王从丛. 双酚A暴露致神经细胞凋亡和炎症性死亡的研究进展,河南师范大学学报202250(1):1-11. lead article, 综述约稿)

(9) Hongxuan Kuang, Zhilin Li, Jianglu Feng, Jianhua Tan, Wangqi Zhu, Shengjie Lin, Qihua Pang, Ruifang Fan*. Volatile organic compounds from second-hand smoke may increase susceptibility of children through oxidative stress damage. Environmental Research, 2022, 207112227. IF2021=8.431

(10) Jianhua Tan#, Hongxuan Kuang#, Xuejing Lv, Yingwei Zeng, Wenji Zhou, Qilai Xie *, Ruifang Fan*. Distribution characteristics and health risk assessment of a novel antibacterial alternative in personal care products: chloroxylenol. Science of the Total Environment, 2021, 786, 147524. (一区)

(11) Hongxuan Kuang, Zhilin Li, Xuejing Lv, Peiqiong Wu, Jianhua Tan, Qiurong Wu, Wenhui Jiang, Qihua Pang, Ruifang Fan*. Exposure to volatile organic compounds may be associated with oxidative DNA damage-mediated childhood asthma. Ecotoxicology and Environmental Safety, 2021, 210: 111864. (IF2019=4.872)

(12) Congcong Wang, Jiaying He, Tongfei Xu, Hongyu Han, Zhimin Zhu, Lingxue Meng, Qihua Pang*, Ruifang Fan*. Bisphenol A(BPA), BPS and BPB-induced oxidative stress and apoptosis mediated by mitochondria in human neuroblastoma cell lines, Ecotoxicology and Environmental Safety, 2021, 207:111299. (IF2019=4.872)

(13) Lingxue Meng, Jian Liu, Congcong Wang, Zedong Ouyang, Jiahua Kuang, Qihua Pang*, Ruifang Fan*. Sex specific neurotoxic effects of BPA and its analogs on primary hippocampal neurons attenuated by EGCG, Chemosphere, 2021, 264, 128450. (IF2019=5.778)

(14) Hongxuan Kuang, Jian Liu, Yingwei Zeng, Wenji Zhou, Peiqiong Wu, Jianhua Tan, Yonghong Li, Qihua Pang, Wenhui Jiang*, Ruifang Fan*. Co-exposure to polycyclic aromatic hydrocarbons, benzene and toluene may impair lung function by increasing oxidative damage and airway inflammation in asthmatic children. Environmental Pollution, 2020, 266,115220. (IF2019=6.792,一区)

(15) Yonghong Li, XueJing Lv, Jian Liu, Jianying He, Lingxue Meng, Hongxuan Kuang, Caihui Cha, Qihua Pang*, Ruifang Fan*, Association between 10 urinary heavy metals exposure and attention deficit hyperactivity disorder for children, Environmental Science and Pollution Research, 2020, 27:31233–31242. SCI, IF2019=3.056

(16) Haibin Zhang, Zhouyu Wang, Lingxue Meng, Hongxuan Kuang, Jian Liu, Xuejing Lv, Qihua Pang, Ruifang Fan*, Maternal exposure to environmental bisphenol A impairs the neurons in hippocampus across generations, Toxicology, 2020, 432:152393. (IF2019=4.099)

(17) Hongxuan Kuang, Yanyan Dai, Yonghong Li, Caihui Cha, Wenhui Jiang, Qihua Pang, Haibin Zhang, Ruifang Fan*. The association among blood BPDE-DNA adducts, serum interleukin-8 (IL-8) and overall DNA damage for children with pulmonary disease. International Journal of Environmental Health Research, 2019, 1-12. (SCI, IF2018=1.465)

(18) Hongxuan Kuang, Yonghong Li, Wenhui Jiang, Peiqiong Wu, Jianhua Tan, Haibin Zhang, Qihua Pang, Ruifang Fan*. Simultaneous determination of urinary 31 VOC metabolites8-hydroxy-2′-deoxyguanosine and trans-3′-hydroxy-cotinine by UPLC-MS/MS: The effect of isotoped internal standards on elimination of matrix effect, Analytical and Bioanalytical Chemistry, 2019, 411:7841-7855. (SCI, IF2018=3.286)

(19) 邝洪轩,张海彬,谭建华,雒亦凡,刘舒华,庞启华,李楚华,范瑞芳*. 维生素C抗氧化-同位素内标稀释-超高效液相色谱串联质谱法同时测定新生期大鼠海马体神经递质的含量,色谱,2019374):404-411

(20) Haibing Zhang, Kuanghong Xuan, Yifan Luo, Shuhua Liu, Lingxue Meng, Qihua Pang, Ruifang Fan*. Low-dose bisphenol A exposure impairs learning and memory ability with alterations of neuromorphology and neurotransmitters in rats, Science of the Total Environment, 2019, 697:134036. 一区)

(21) Qihua Pang#, Yanru Li#, Lingxue Meng, Guanyong Li, Zhiwei Luo, Ruifang Fan*. Neurotoxicity of BPA, BPS and BPB for the hippocampal cell line (HT-22): an implication for the replace of BPA in plasticsChemosphere, 2019, 226:545-552. (SCI, IF2018=5.108, 2)

(22) Laiguo Chen, Guocheng Hu, Ruifang Fan*, Yanshan Lv, Yanyan Dai, Zhencheng Xu*. Association of PAHs and BTEX exposure with lung function and respiratory symptoms among non-occupational population near the coal-chemical industry in Northern China. Environment International, 2018, 120:480-488. (1)

(23) Yanru Li, Haibin Zhang, Hongxuan Kuang, Ruifang Fan*, Caihui Cha*, Guanyong Li, Zhiwei Luo, Qihua Pang. Relationship between Bisphenol A exposure and Attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Environmental Pollution, 2018, 235:141-149. (SCI, IF2018=5.714)

(24) Yuanxiu Zhou, Zhouyu Wang, Minghan Xia, Siyi Zhuang, Xiaobing Gong*, Jianwen Pan, Chuhua Li, Ruifang Fan*, Qihuang Pang, Shaoyou Lu. Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: An implication for children exposed to environmental level of BPA, Environmental Pollution, 2017, 229:40-48. (SCI, IF2017=4.358)

(25) Yanshan Lv#, Shaoyou Lu#, Yanyan Dai, Caiyan Rui, Yongjun Wang, Yanru Li, Yuanxiu Zhou, Qihua Pang, Ruifang Fan*. Higher dermal exposure of cashiers to BPA and its association with DNA oxidative damage, Environment International, 2017, 98:69-74. ( 1).

 

国家发明专利一项:

范瑞芳,液相色谱串联质谱分析尿液中苯和甲苯四种代谢产物的方法,授权专利号:ZL-201310067770.3,授权日期:201442日。(已转让)