华南师范大学生命科学院教授,博士研究生导师,博士,生物工程系主任。2010年9月-2012年3月获国家留学基金委资助,赴美国加州公共卫生局(California Department of Public Health)访学。广东省环境诱变剂学会副理事长,华南师范大学-番禺中心医院基础与转化医学联合实验室客座教授,广东省环境科学学会生态毒理学与环境毒理学分会&环境暴露与健康风险控制专业委员会委员。
长期从事环境持久性有机污染物人群暴露监测、环境污染物毒理及分子机制研究。主持国家和省部级基金20余项,在国内外发表中英文论文100余篇,其中90篇被SCI及EI收录,引用合计2000余次,H指数为29,高被引论文一篇。曾多次获得华南师范大学 “科研工作优秀奖” “优秀班主任”以及“优秀教师”等荣誉称号,已培养毕业4位博士、23位硕士研究生,多名研究生获得“国家奖学金”、“广东省优秀学生(研究生)”以及校级“优秀硕士论文”等奖励和荣誉称号;指导本科生获得广东大学生课外学术科技作品竞赛二等奖”及全国大学生生命科学竞赛二等奖&广东赛区一等奖。
论文专著(#第一作者,*通讯作者):
(1) Lingxue Meng, Zedong Ouyang, Yuxin Chen, Chengmeng Huang, Yunjiang Yu, Ruifang Fan*. Low-dose BPA-induced abnormal neuronal energy metabolism and apoptosis mediated by PINK1/parkin mitophagy pathway in juvenile rats, Science of the Total Environment, 2024, 929:172655.
(2) Wucheng Yang, Jianglu Feng, Wenyao Liang, Mingxia Nie, Jianhua Tan*, Ruifang Fan*. A high- throughput method for the determination of 14 UV-filters in human plasma by LC-MS/MS: minimize interference from proteins and phospholipids, Journal of Chromatography B, 2024,1237:124090. (IF2022=3.0)
(3) Jian Liu, Jiaying He, Zengquan Liao, Xiaolin Chen, Yufeng Ye, Qihua Pang, Ruifang Fan*. Environmental doses of 16 priority-controlled PAHs induce endothelial dysfunction: an in vivo and in vitro study. 2024, Science of the Total Environment, 2024, 919, 170711. (IF2022=9.8)
(4) Zengquan Liao; Zhilin Li; Maorong Wu; Keqin Zeng; Hongyu Han; Chao Li; Ruifang Fan, Qihua Pang*. Heavy metal exposure and risk assessment of local dominant fish species in the Beijiang River Basin of China: a 60 years’ follow-up study. Science of the Total Environment, 2023, 922: 166322. (IF2022=9.8)
(5) Lingxue Meng, Shiheng Gui, Zedong Ouyang, Yajuan Wu, Youling Zhuang, Qihua Pang, Ruifang Fan*, Low dose bisphenols sex-specifically induce neurodevelopmental toxicity in juvenile rats and the antagonism of EGCG, Journal of Hazardous Materials, 2023, 459:132074. (IF2022=13.6)
(6) Lei Wang, Chengmeng Huang, Leizi Li, Qihua Pang, Congcong Wang, Ruifang Fan*. In vitro and in silico assessment of GPER-dependent neurocytotoxicity of emerging bisphenols. Science of the Total Environment, 2023, 862, 160762. (IF2022=9.8)
(7) Zhilin Li, Hongxuan Kuang, Leizi Li, Maorong Wu, Zengquan Liao, Keqin Zeng, Yufeng Ye*, Ruifang Fan. What adverse health effects will environmental heavy metal co-exposure bring us: Based on a biological monitoring study of sanitation workers, Environmental Science and Pollution Research, 2023, 30, 35769–35780. (IF2022=5.8)
(8) Hongxuan Kuang, Yonghong Li, Leizi Li, Shengtao Ma, Taicheng An*, Ruifang Fan*. Four-year population exposure study: Implications for the effectiveness of e-waste control and biomarkers of e-waste pollution. Science of the Total Environment, 2022, 42:156595. (IF2022=9.8).
(9) Congcong Wang, Lei Wang, Chengmeng Huang, Yungang Liu, Qihua Pang, Hongyu Han, Ruifang Fan*. Involvement of NLRP3-/Caspase-1-/GSDMD- dependent pyroptosis attenuates BPA-induced apoptosis of neuroblastoma cells. Biochemical Pharmacology,2022, 200:11542. (IF2022=5.8)
(10) Xuejing Lv#, Jianhua Tan#, Jianglu Feng, Zhilin Li, Weiran Gong, Dingguo Zhang, Hongxuan Kuang, Ruifang Fan* Relationship of polycyclic aromatic hydrocarbons exposure with vascular damages among sanitation workers. Journal of Environmental Science and Health, Part C (Toxicology and Carcinogenesis), 2022, 40(2): 154-171. (IF2022=2.5)
(11) Hongxuan Kuang, Wenji Zhou, Yingwei Zeng, Da Xu, Wanqi Zhu, Shengjie Lin, Ruifang Fan*. Dose makes poison: Insights into the neurotoxicity of perinatal and juvenile exposure to environmental doses of 16 priority-controlled PAHs. Chemosphere, 2022, 134201. (IF2022=8.8)
(12) Jiaying He#, Qihua Pang#, Chengmeng Huang, Jiaqi Xie, Jindian Hu, Lei Wang, Congcong Wang, Lingxue Meng, Ruifang Fan*. Environmental dose of 16 priority-controlled PAHs mixture induces vascular endothelial cells dysfunction through oxidative stress. Toxicology in Vitro, 2022, 79:105296. (IF2022=3.2)
(13) 范瑞芳,王从丛. 双酚A暴露致神经细胞凋亡和炎症性死亡的研究进展,河南师范大学学报,2022,50(1):1-11. (封面文章, 综述约稿)
(14) Hongxuan Kuang, Zhilin Li, Jianglu Feng, Jianhua Tan, Wangqi Zhu, Shengjie Lin, Qihua Pang, Ruifang Fan*. Volatile organic compounds from second-hand smoke may increase susceptibility of children through oxidative stress damage. Environmental Research, 2022, 207:112227. (IF2022=8.3)
(15) Jianhua Tan#, Hongxuan Kuang#, Xuejing Lv, Yingwei Zeng, Wenji Zhou, Qilai Xie *, Ruifang Fan*. Distribution characteristics and health risk assessment of a novel antibacterial alternative in personal care products: chloroxylenol. Science of the Total Environment, 2021, 786, 147524. (IF2021=10.753)
(16) Hongxuan Kuang, Zhilin Li, Xuejing Lv, Peiqiong Wu, Jianhua Tan, Qiurong Wu, Wenhui Jiang, Qihua Pang, Ruifang Fan*. Exposure to volatile organic compounds may be associated with oxidative DNA damage-mediated childhood asthma. Ecotoxicology and Environmental Safety, 2021, 210: 111864.
(17) Congcong Wang, Jiaying He, Tongfei Xu, Hongyu Han, Zhimin Zhu, Lingxue Meng, Qihua Pang*, Ruifang Fan*. Bisphenol A(BPA), BPS and BPB-induced oxidative stress and apoptosis mediated by mitochondria in human neuroblastoma cell lines, Ecotoxicology and Environmental Safety, 2021, 207:111299. (IF2021=7.129,SCI高被引)
(18) Lingxue Meng, Jian Liu, Congcong Wang, Zedong Ouyang, Jiahua Kuang, Qihua Pang*, Ruifang Fan*. Sex specific neurotoxic effects of BPA and its analogs on primary hippocampal neurons attenuated by EGCG, Chemosphere, 2021, 264, 128450. (IF2021=8.943)
(19) Hongxuan Kuang, Jian Liu, Yingwei Zeng, Wenji Zhou, Peiqiong Wu, Jianhua Tan, Yonghong Li, Qihua Pang, Wenhui Jiang*, Ruifang Fan*. Co-exposure to polycyclic aromatic hydrocarbons, benzene and toluene may impair lung function by increasing oxidative damage and airway inflammation in asthmatic children. Environmental Pollution, 2020, 266,115220. (IF2020=8.071)
(20) Yonghong Li, XueJing Lv, Jian Liu, Jianying He, Lingxue Meng, Hongxuan Kuang, Caihui Cha, Qihua Pang*, Ruifang Fan*, Association between 10 urinary heavy metals exposure and attention deficit hyperactivity disorder for children, Environmental Science and Pollution Research, 2020, 27:31233–31242. (IF2020=4.233)
(21) Haibin Zhang, Zhouyu Wang, Lingxue Meng, Hongxuan Kuang, Jian Liu, Xuejing Lv, Qihua Pang, Ruifang Fan*, Maternal exposure to environmental bisphenol A impairs the neurons in hippocampus across generations, Toxicology, 2020, 432:152393. (IF2020=4.221)
(22) Hongxuan Kuang, Yanyan Dai, Yonghong Li, Caihui Cha, Wenhui Jiang, Qihua Pang, Haibin Zhang, Ruifang Fan*. The association among blood BPDE-DNA adducts, serum interleukin-8 (IL-8) and overall DNA damage for children with pulmonary disease. International Journal of Environmental Health Research, 2019, 1-12. (IF2019=1.916)
(23) 邝洪轩,张海彬,谭建华,雒亦凡,刘舒华,庞启华,李楚华,范瑞芳*. 维生素C抗氧化-同位素内标稀释-超高效液相色谱串联质谱法同时测定新生期大鼠海马体神经递质的含量,色谱,2019,37(4):404-411。
(24) Hongxuan Kuang, Yonghong Li, Wenhui Jiang, Peiqiong Wu, Jianhua Tan, Haibin Zhang, Qihua Pang, Ruifang Fan*. Simultaneous determination of urinary 31 VOC metabolites,8-hydroxy-2′-deoxyguanosine and trans-3′-hydroxy-cotinine by UPLC-MS/MS: The effect of isotoped internal standards on elimination of matrix effect, Analytical and Bioanalytical Chemistry, 2019, 411:7841-7855. ( IF2019=3.637)
(25) Haibing Zhang, Kuanghong Xuan, Yifan Luo, Shuhua Liu, Lingxue Meng, Qihua Pang, Ruifang Fan*. Low-dose bisphenol A exposure impairs learning and memory ability with alterations of neuromorphology and neurotransmitters in rats, Science of the Total Environment, 2019, 697:134036. (IF2019=6.551)
(26) Laiguo Chen, Guocheng Hu, Ruifang Fan*, Yanshan Lv, Yanyan Dai, Zhencheng Xu*. Association of PAHs and BTEX exposure with lung function and respiratory symptoms among non-occupational population near the coal-chemical industry in Northern China. Environment International, 2018, 120:480-488. (SCI2018=7.943, 1区)
(27) Yanru Li, Haibin Zhang, Hongxuan Kuang, Ruifang Fan*, Caihui Cha*, Guanyong Li, Zhiwei Luo, Qihua Pang. Relationship between Bisphenol A exposure and Attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Environmental Pollution, 2018, 235:141-149. (SCI2018=5.714, 2区)
(28) Yuanxiu Zhou, Zhouyu Wang, Minghan Xia, Siyi Zhuang, Xiaobing Gong*, Jianwen Pan, Chuhua Li, Ruifang Fan*, Qihuang Pang, Shaoyou Lu. Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: An implication for children exposed to environmental level of BPA, Environmental Pollution, 2017, 229:40-48. (SCI2017=4.358, 2区)
(29) Yanshan Lv#, Shaoyou Lu#, Yanyan Dai, Caiyan Rui, Yongjun Wang, Yanru Li, Yuanxiu Zhou, Qihua Pang, Ruifang Fan*. Higher dermal exposure of cashiers to BPA and its association with DNA oxidative damage, Environment International, 2017, 98:69-74. (SCI2017=7.297, 1区). (代表作)
(30) Yanshan Lv, Caiyan Rui, Yanyan Dai, Qihua Pang, Yanru Li, Ruifang Fan*, Shaoyou Lu*. Children exposure to BPA through dust and the association of urinary BPA, triclosan with oxidative stress in Guangzhou, China. Environmental Science: processes & impact, 2016, 18: 1492-1499. (SCI, IF2016=2.592)
(31) Shaoyou Lu, Lu Ren, Jianzhang Fang, Jiajia Ji, Guihua Liu, Jianqing Zhang, Huimin Zhang, Ruorong Luo, Kai Lin, Ruifang Fan*. Trace elements can increase urinary 8-hydroxy-2’-deoxyguanosine level: a case study of college students in Guangzhou, China. Environmental Science and Pollution Research, 2016, 23:8484–8491. (SCI, IF2016=2.741)
(32) 周苑秀,李敏杰,钟伟红, 范瑞芳*. 彗星电泳法测定双酚A对雄性小鼠脑细胞的DNA损伤.生态毒理学报,2016,11(2):666-671。
(33) Junnan Li#, Shaoyou Lu#, Guihua Liu, Yuanxiu Zhou, Yan Shan Lv, Jianwen She, Ruifang Fan*. Co-exposure to polycyclic aromatic hydrocarbons, benzene and toluene and their dose-effects on oxidative stress damage in kindergarten-aged children in Guangzhou, China. Science of the Total Environment, 2015, 524-525: 74-80. (SCI, IF2015=4.099, 1区).
(34) Ruifang Fan*, Biyan Zeng, Xiaosu Liu, Chao Chen, Qinwei Zhuang, Yongjun Wang, Mingli Hu, Yanshan Lv, Junnan Li, Yuanxiu Zhou, Zhi Yuan (William) Lin. Levels of bisphenol-A in different paper products in Guangzhou, China and assessment of human exposure via dermal contact. Environmental Science: Processes & Impacts, 2015, 17:667-673. (SCI, IF2015=2. 401)
(35) Ruifang Fan*, Dongli Wang, Jianwen She. Method development for the simultaneous analysis of trans, trans-muconic acid, 1, 2-dihydroxybenzene, S-phenylmercapturic acid and S-benzylmercapturic acid in human urine by liquid chromatography/tandem mass spectrometery. Analytical Methods, 2015, 7: 573-580. (SCI, IF2015=1.821)
(36) Junnan Li, Ruifang Fan*, Shaoyou Lu*, Dongru Zhang,Yuanxiu Zhou, Yanshan Lv. Exposure to polycyclic aromatic hydrocarbon could cause their oxidative DNA damage: A case study for college students in Guangzhou, China. Environmental Science and Pollution Research, 2015, 22: 1770-1777. (SCI, IF2015=2.828)
(37) Ruifang Fan, Junnan Li, Laiguo Chen*, Zhencheng Xu*, Dechun He, Yuanxiu Zhou, Yuanyuan Zhu, Fusheng Wei Jihua Li. Biomass fuels and coke plants are important sources of human exposure to polycyclic aromatic hydrocarbons, benzene and toluene. Environmental Research, 2014, 135: 1–8. (SCI, IF2014=4.373)
(38) Ruifang Fan*, Dongli Wang, Chuanwei Mao, Shangkang Ou, Zhixia Lian, Shaoling Huang, Qiongshan Lin, Runhao Ding, Jianwen She. Preliminary study of children’s exposure to PAHs and its association with 8-hydroxy-2’-deoxyguanasine in Guangzhou, China. Environment International, 2012, 42: 53-58. (SCI, IF2012 = 6.248,一区)
(39) Ruifang Fan, Robert Ramage, Dongli Wang, Junqiang Zhou, Jianwen She*. Determination of ten monohydroxylated polycyclic aromatic hydrocarbons by liquid-liquid extraction and liquid chromatography/tandem mass spectrometry. Talanta, 2012, 93: 383-395. (SCI, IF2012 = 3.498,一区)
(40) Ruifang Fan, Dongli Wang, Robert Ramage, Jianwen She*. Fast and simultaneous determination of urinary 8-hydroxy-2'-deoxyguanosine and ten monohydroxylated polycyclic aromatic hydrocarbons by liquid chromatography/tandem mass spectrometery. Chemical Research in Toxicology, 2012, 25(2) 491-499. (SCI, IF2012= 3.667.)
(41) Ruifang Fan, Yulian Dong, Wenbing Zhang*, Yu Wang, Guoying Sheng, Jiamo Fu, Fast simultaneous determination of urinary 1-hydroxypyrene and 3-hydroxybenzo[a]pyrene by liquid chromatography–tandem mass spectrometry, J. Chromatogr. B, 2006, 836, 92-97. (SCI收录,IF=2.647)
专利:
1. 范瑞芳,液相色谱串联质谱分析尿液中苯和甲苯四种代谢产物的方法,授权专利号:ZL-201310067770.3,授权日期:2014年4月2日。(已转让)