研究员,博士生导师。入选“国家高层次人才特殊支持计划青年拔尖人才”和“广东省百名博士博士后创新人物”;“广东省杰出青年基金”和“岭南动植物科学技术奖-杰出青年奖”获得者。华南师范大学昆虫科学与技术研究所副所长和广州市昆虫发育调控与应用研究重点实验室副主任。西北农林科技大学-美国加州大学戴维斯分校联合培养博士,2017年作为师资博后入职华南师范大学,于2019年初作为青年拔尖人才留校任教并受聘为副教授,2021年晋升为研究员。
作为通讯作者/第一作者(含共同)在Nature Communications (2018 2023), Cell Reports (2024), Science Advances (2024), Trends in Biotechnology (2019), The Innovation (2023), Nucleic Acids Research (2017), Science China Life Sciences (2024), Cellular and Molecular Life Sciences (2014 2015), STAR Protocols (2024)和Cell Regeneration (2023)等国际刊物上发表论文多篇。申请并授权国家发明专利10项,已成功进行成果转化4项。
主持中组部特支计划青年拔尖人才项目(2024)、国家自然科学基金面上项目(2020、2023)/青年项目(2017)、广东省自然科学基金杰青项目(2020)/面上项目(2019)、广州市自然科学基金科技菁英领航项目(2023)/面上项目(2020)、博士后科学基金面上项目(2017)等。
担任Elsevier出版集团丛书审稿人,Nucleic Acids Research、Genome Research、Molecular Therapy、Molecular Therapy- Methods & Clinical Development等高水平SCI期刊审稿人。
中国昆虫学会第十一届理事会昆虫发育与遗传专业委员会委员(2023-),中国动物学会比较内分泌学专业委员会委员(2022-),The Innovation期刊青年编委(2024-),广东省生化与分子生物学会青年委员,国际再生生物学学会(ISRB)会员。
15篇代表性论文(#第一作者,*通讯作者):
1 Zheng Zhao#, Liang Li#, Ruichen Zeng, Liangguan Lin, Dongwei Yuan, Yejie Wen, Na Li, Yingying Cui, Shiming Zhu, Zhi-Min Zhang, Sheng Li*, and Chonghua Ren*. 5mC modification orchestrates choriogenesis and fertilization by preventing prolonged ftz-f1 expression. Nature Communications. 2023 Dec 12;14(1):8234 (IF=16.6)
2 Chonghua Ren# *, Yejie Wen#, Shaojuan Zheng#, Zheng Zhao#, Ethan Yihao Li, Chenjing Zhao, Mingtao Liao, Liang Li, Xiaoshuai Zhang, Suning Liu, Dongwei Yuan, Wei Wang, Jifeng Fei, Sheng Li*. Two transcriptional cascades orchestrate cockroach leg regeneration. Cell Reports. 2024.43(3) 113889. DOI: 10.1016/j.celrep.2024.113889
3 Xiaoshuai Zhang# *, Lin Wei#, Wei Zhang, Feixue Zhang, Lin Li, Liang Li, Yejie Wen, Jiahui Zhang, Suning Liu, Dongwei Yuan, Yanmei Liu, Chonghua Ren*, Sheng Li*. ERK-activated CK-2 triggers blastema formation during appendage regeneration. Science Advances. 2024 10:adk8331
4 Henriette O’Geen#, Chonghua Ren#, Charles M. Nicolet, Andrew A. Perez, Julian Halmai, Victoria M. Le, Joel P. Mackay, Peggy J. Farnham and David J. Segal*. dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. Nucleic Acids Research. 2017. DOI: 10.1093/nar/gkx578 (共同第一作者) (IF=19.16)
5 Xingmei Mai#, Mingtao Liao#, Fangming Zhao#, Ethan Yihao Li, Fangzheng Liu, Renaguli Aisa, Sichen Wu, Nan Chen, Sheng Li*, Chonghua Ren*. Hox-determined appendage regeneration restores cockroach courtship rituals. SCIENCE CHINA-Life Sciences. 2024 In press
6 Chonghua Ren#, Nan Chen#, Sheng Li*. Harnessing “Little Mighty” cockroaches:Pest management and beneficial utilization. The Innovation. 2023. 4(6).100531. (IF=33.1)
7 Jiru Zhong#, Andi Jing#, Shaojuan Zheng, Sheng Li, Xiaoshuai Zhang* and Chonghua Ren*. Physiological and molecular mechanisms of insect appendage regeneration. Cell Regeneration. 2023 12:9
8 Liang Li#, Kai Cheng#, Jiru Zhong#, Shaojuan Zheng#, Chenjing Zhao, Yejie Wen, Sheng Li, and Chonghua Ren*. Protocol for high-resolution 3D visualization of insect regenerating legs through micro-computed tomography. STAR Protocols. 2024.5(4) 103342
9 Chonghua Ren#, Kun Xu#, David Jay Segal*, Zhiying Zhang*. Strategies for the enrichment and selection of genetically modified cells. Trends in Biotechnology. 37(1) 2019 pp. 56-71 (IF=21.942)
10 Sheng Li#*, Shiming Zhu#, Qiangqiang Jia#, Dongwei Yuan#, Chonghua Ren#, Kang Li, Suning Liu, Yingying Cui, Haigang Zhao, Yanghui Cao, Gangqi Fang, Daqi Li, Xiaoming Zhao, Jianzhen Zhang, Qiaoyun Yue, Yongliang Fan, Xiao-Qiang Yu, Qili Feng, and Shuai Zhan*. The genomic and functional landscapes of developmental plasticity in the American cockroach. Nature Communications. 2018. DOI: 10.1038/s41467-018-03281-1 (共同第一作者) (IF=16.6)
11 Chonghua Ren#, Kun Xu#, Zhongtian Liu, Juncen Shen, Furong Han, Zhilong Chen, Zhiying Zhang*. Dual-reporter surrogate systems for efficient enrichment of genetically modified cells. Cellular and Molecular Life Sciences. 2015. 72(14), p. 2773-4 (IF= 9.234)
12 Kun Xu#, Chonghua Ren#, Zhongtian Liu, Tao Zhang, Tingting Zhang, Duo Li, Ling Wang, Qiang Yan, Lijun Guo, Juncen Shen, Zhiying Zhang*. Efficient genome engineering in eukaryotes using Cas9 from Streptococcus thermophilus. Cellular and Molecular Life Sciences. 72 (2) (2014), pp. 383-399 (共同第一作者)
13 Liang Li#, Andi Jing#, Minxin Xie, Sheng Li, Chonghua Ren*. Applications of RNA interference in American cockroach. Journal of Visualized Experiments. 2021 Dec 17;(178).
14 Zheng Zhao#, Liang Li#, Min Cheng#, Andi Jing, Suning Liu, Shiming Zhu, Erxia Du, Sheng Li, Yunxia Luan*, Chonghua Ren*. Grainy head signaling regulates epithelium development and ecdysis in Blattella germanica. Insect Science. 2021 Apr;28(2):485-494
15 Na Li#, Mei Zeng#, Huilu Xiao, Shuren Lin, Shuting Yang, Haixin Huang, Shiming Zhu, Zheng Zhao, Chonghua Ren*, Sheng Li*. Alteration of insulin and nutrition signal gene expression or depletion of Met reduce both lifespan and reproduction in the German cockroach. Journal of Insect Physiology 2019 Oct;118:103934
授权专利
1 任充华,李胜。一种dsRNA及其在防治德国小蠊上的应用。发明专利,申请或专利号:ZL201810775922.8 (授权日期:2019.07.12)
2 任充华,李胜。美洲大蠊断肢再生相关Wingless信号通路基因及其dsRNA的应用。发明专利,申请或专利号:ZL201810775847.5 (授权日期:2019.06.28)
3 李胜,任充华。美洲大蠊断肢再生相关Hedgehog信号通路基因及其dsRNA的应用。发明专利,申请或专利号:ZL201810883915.X (授权日期:2019.08.27)
4 任充华,李胜,赵政。与德国小蠊表皮发育相关的Cad96ca基因、该基因的dsRNA及其制备方法与应用。发明专利,专利号:ZL201910976989.2 (授权日期:2020.09.01)
5 李胜,任充华,赵政。与德国小蠊表皮发育相关的Grh基因、该基因的dsRNA及其制备方法与应用。发明专利,专利号:ZL201910977154.9 (授权日期:2020.11.10)
6 任充华,李胜,李靓。基于美洲大蠊HDAC1基因设计的dsRNA、其制备方法、编码基因及其应用。发明专利,专利号:ZL202011228116.2 (授权日期:2021.06.08)
7 任充华,温叶杰,郑少娟,李胜。zfh-2基因在肢体再生及害虫防治中的应用。发明专利,专利号:ZL202310757700.4 (授权日期:2024.01.23)
8 任充华,郑少娟,温叶杰,李胜。bowl基因在肢体再生及害虫防治中的应用。发明专利,专利号:ZL202310757592.0 (授权日期:2024.02.19)
9 赵政,曾睿辰,任充华,李胜。德国小蠊Dnmt1基因在肢体再生及害虫防治中的应用。发明专利,专利号:ZL202310629082.5 (授权日期:2023.12.26)
10 张智英,白义春,徐坤,魏泽辉,和林洁,任充华,邵斯旻,吴芸,刘中天。一种利用CRISPR/Cas9技术基于SSA修复的基因无缝编辑方法。发明专利,专利号: ZL201610333062.3 (授权日期:2019.10.11)