张新帅研究员个人简介

个人简介：

张新帅，博士，研究员。2012年毕业于美国新墨西哥大学(University of New Mexico), 获化学博士学位。2012年至2019年在美国伊利诺伊大学香槟分校基因组生物学研究所(Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign)从事博士后研究。2019年3月作为青年拔尖人才引进到华南师范大学生命科学学院生态科学研究所。共发表SCI收录研究论文17篇，其中以第一作者或共同第一作者在Nature Chemical Biology，Proc. Natl. Acad. Sci. U. S. A.，J. Am. Chem. Soc.，eLife，Angew. Chem. Int. Ed.，ACS Catalysis等国际权威期刊上发表研究论文7篇。

主要研究方向：

主要从事分子层面上的微生物代谢研究，利用“基因组酶学”策略解析微生物新酶功能及其参与的代谢通路。解析肠道微生物中最富集的甘氨酰自由基蛋白家族新酶功能，在分子层面上阐明肠道微生物代谢膳食成分和外源性成分的生化分子基础。

代表性论文：

1. Carter, M. S.^&, Zhang, X.^&, Huang, H.^&, Bouvier, J. T., San Francisco, B., Vetting, M. W., Al-Obaidi, N., Bonanno, J. B., Ghosh, A., Zallot, R., Andersen, H. M., Almo, S. C., and Gerlt, J. A. “Functional Assignment of Multiple Catabolic Pathways for D-apiose” Nat. Chem. Biol. 2018, 14, 696-705. ^&Equal contribution (IF: 15.066).

2. Zhang, X., Carter, M. S., Vetting, M. W., San Francisco, B., Zhao, S., Al-Obaidi, N., Solbiati, J. O., Thiaville, J. J., de Crécy-Lagard, V., Jacobson, M. P., Almo, S. C., and Gerlt, J. A. “Assignment of Function to a Domain of Unknown Function (DUF): DUF1537 is a New Kinase Family in Catabolic Pathways for Acid Sugars” Proc. Natl. Acad. Sci. U. S. A. 2016, E4161-E4169 (IF: 9.423).

3. Zhang, X., Kumar, R., Vetting, M. W., Zhao, S., Jacobson, M. P., Almo, S. C., and Gerlt, J. A. “A Unique cis-3-Hydroxy-L-Proline Dehydratase in the Enolase Superfamily” J. Am. Chem. Soc.  2015, 137, 1388-1391. (IF: 13.038)

4. Zhang, X., Song, X., Li, H., Zhang, S., Chen, X., Yu, X., and Wang, W. “An Organocatalytic Cascade Approach toward Polysubstituted Quinolines and Chiral 1,4-Dihydroquinolines-Unanticipated Effect of N-Protecting Groups” Angew. Chem. Int. Ed., 2012, 51, 7282-7286. (IF: 11.709) (This work was highlighted in Synfacts and ChemInform)

5. Zhang, X., Zhang, S., and Wang, W. “Iminium–Allenamine Cascade Catalysis: One-Pot Access to Chiral 4H-Chromenes by a Highly Enantioselective Michael-Michael Sequence” Angew. Chem., Int. Ed. 2010, 49, 1481-1484. (IF: 11.709) (This work was highlighted in Synfacts and ChemInform)

6. Zhao, S.^&, Sakai, A.^&, Zhang, X.^&, Vetting, M. W.^&, Kumar, R.^&, Hillerich, B., San Francisco, B., Solbiati, J. O., Steves, A., Brown, S., Akiva, E., Barber, A., Seidel, R. D., Babbitt, P. C., Almo, S. C., Gerlt, J. A., and Jacobson, M. P. “Prediction and Characterization of Enzymatic Activities Guided by Sequence Similarity and Genome Neighborhood Networks” eLife 2014, 10.7554/eLife.03275. ^&Equal contribution (IF: 8.303)

7. Huang, H.^&, Zhang, X.^&, Yu, C., Li, X., Zhang, Y., and Wang, W. “Highly Regio- and Stereoselective Synthesis of Z and E Enol Esters by an Amine-Catalyzed Conjugate Addition–Rearrangement Reaction of Ynals with Carboxylic Acids” ACS Catal. 2016, 6, 8030–8035. ^&Equal contribution (IF: 9.307)

联系方式：

华南师范大学生命科学学院-生态科学研究所310室

Email: xszhang@scnu.edu.cn