关燕清教授简介

华南师范大学生命科学学院/关燕清 2018-01-10 17:46:00 来源:华南师范大学生命科学学院 点击: 收藏本文

一、个人简介:

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关燕清,女,理学博士,教授,博士生导师,纳米靶向细胞生物学及肿瘤等重大疾病治疗技术方向的学术带头人,珠江学者(2014)。

1995年至2005年在日本京都大学材料化学系(联培,师从日本高分子学会会长今西幸男)、华南师范大学生命科学学院以及暨南大学临床医学院攻读硕士、博士学位和进行博士后研究。

长期在生物材料与细胞生物学的交叉领域辛勤耕耘。自2010年在生物材料排名第一的国际权威刊物Biomaterials (IF=8.402)上发表了4篇系列学术论文,深入阐明了抗癌靶向药物的细胞生物学效应和机制。近五年以第一或通讯作者发表SCI论文总影响因子为76.053,平均5.85/篇。近五年以第一发明人授权国家发明专利7项(企业洽谈转让3项),新申请15项。近五年已完成3项国家基金面上项目和4项广东省基金及科技计划项目,主要参与1项国家高技术研究发展计划(863计划)等项目。目前主持1项广东省公益研究与能力建设专项资金。2016年申请国家基金-广东联合基金重点项目(会审)。是国际刊物Biomaterials,ACS Applied Materials & Interfaces,Biomacromolecules,Langmuir等的审稿人。

曾获华南师范大学科研优秀奖(2010),华南师范大学实践教学优秀奖(2012),华南师范大学教学成果一等奖(2017),生命科学学院课外科研优秀导师(2012)。主讲本科生《生物材料学》(2017课堂教学质量评估成绩:97.614分),研究生《现代生物医药专题》、《高级细胞生物学》等核心课程。近五年,指导和培养博士生、硕士生、本科生获得十多篇优秀毕业论文。并荣获两届(2012,2014)华南师范大学“十佳”博士学术论文(排名均第一)、广东省科技挑战杯“特等奖”(2015)及“一等奖”(2011)、四人次教育部国家奖学金(2012,2013,2016(2))、广东省优秀硕士生(2017)、香江学者(2016)等荣誉。

所带领的“生物材料实验室”(Biomaterials Lab,2009年筹建)有较好的研究积累。目前课题组有3名副高级研究人员,2名讲师,已结题国家基金2项,正在承担省、市级项目3项。目前实验室有17名博硕士研究生,20名本科生,完成研究生创新基金2项(2014,2016,结题优秀),承担1项;完成本科生国家级大创(2017,结题优秀)、金种子(2016,结题优秀)等项目13项,目前承担3项大学生课题。 

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 2018年1月19日Biomaterials Lab期末火炉山烧烤和颁奖活动

 

(左起:尹亮博士、张令坤、张丽、孟展、陈吾雅、张豫骁、杜世伟)

 

 

   二、课题组成员及在读研究生(专业):

1.  课题组成员:李楚华副教授、吴宝艳副研究员、金鹰副研究员、尤蓉博士、尹亮博士

2.  博士研究生:陈吾雅(细胞)、张丽(细胞)、张令坤(细胞)。

3.  硕士研究生:张豫骁(分子)、胡凯凯(化学)、汪慧敏(细胞)、孟展(分子)、韩凯斌(药学)、班晴(细胞)、杜世伟(细胞)、李健(生物医学光子学)、薛永永(生物医学光子学)、王娜(生物医学光子学)、王兰青(药学)、李明超(细胞)、刘丽(神经生理,李楚华)、董钟思玮(神经生理,李楚华)。

 

三、主要研究兴趣:

1.  生物材料调控下哺乳动物细胞周期的阻滞和细胞凋亡的生物化学途径;

2.  纳米药物合成、表征及输送(针对癌症、神经退行性疾病以及糖尿病等重大疾病);

3.  组织工程与生物材料。

 

   四、 近年代表性论著:

 

1.  Li J, Zhang YX, Chen LY, Lu XH, Li ZB,  Guan YQ*. Cervical cancer HeLa cell autocrine apoptosis induced by co-immobilized TNF-α plus IFN-γ. ACS Appl Mater Interfaces 2018; Accepted  (SCI indexed, IF:7.504)

 

2. Hu KK+, Chen XH+, Huang XH, Yin L, You R, Li CH, Guan YQ*. Preparation of Gold Nanoparticles Composites and Inhibition of Apoptosis in Parkinson's disease Cell Model. Nanomed-Nanotechnol 2018; Accepted. (SCI indexed, IF: 5.720)   

 

3. Du SW+, Zhang LK+, Han KB, Hu K, Chen SP, Hu ZY, Yin L, Wu BY, Guan YQ*. Combined PC and HMME for breast cancer treatment via photosensitizers modified Fe3O4 nanoparticles inhibiting the proliferation and migration of MCF-7 cells. Biomacromolecules 2018; 19(1): 31-41 (SCI indexed, IF: 5.246)

http://pubs.acs.org/doi/10.1021/acs.biomac.7b01197

4. Yin L+, Meng Z+, Zhang YX, Hu KK, Chen WY, Han KB, Wu BY, You R, Li CH, Jin Y, Guan YQ*. Bacillus spore-based oral carriers loading curcumin for the therapy of colon cancer. J Control Release 2018; 271: 31-44. (SCI indexed, IF: 7.786) http://www.sciencedirect.com/science/article/pii/S0168365917310799

5. Chen WY+, Wang WW, Chen LY, Chen JM, Lu XH, Li ZB, Wu BY, Yin L, Guan YQ*. Long-term G1 cell cycle arrest in cervical cancer cells induced by co-immobilized TNF-a plus IFN-c polymeric drugs. J Mater Chem B 2018; 6(2): 327-36 (SCI indexed, IF: 4.543)

http://pubs.rsc.org/en/content/articlelanding/2018/tb/c7tb02608k#!divAbstract

6. Zhang YX+, Zhang L+, Li J, Ban Q, Li CH, Guan YQ*. Preparation and characterization of hydroxyapatite nanoparticles carrying insulin and gallic acid for insulin oral delivery. Nanomed-Nanotechnol 2018; 14(2): 353-364. (SCI indexed, IF: 5.720) http://www.sciencedirect.com/science/article/pii/S1549963417302071

7. Zhang L, Zhang YX, Qiu JN, Li J, Chen WY, Guan YQ*. Preparation and characterization of hypoglycemic nanoparticles for oral insulin delivery. Biomacromolecules. 2017; 18(12): 4281-91. (SCI indexed, IF: 5.246)

http://pubs.acs.org/doi/10.1021/acs.biomac.7b01322

8. Zhao MY, Chen LY, Chen WY, Meng Z, Hu KK, Du SW, Zhang L, Yin L, Wu BY, Guan YQ*. Packaging cordycepin phycocyanin micelles for the inhibition of brain cancer. J Mater Chem B 2017; 5(30): 6016-26. (SCI indexed, IF: 4.543)

http://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb00994a#!divAbstract

9. Niu SQ+, Zhang LK+, Zhang L, Zhuang SY, Zhan XY, Chen WY, Du SW, Yin L, You R, Li CH, Guan YQ*. Inhibition by multifunctional magnetic nanoparticles loaded with alpha-synuclein RNAi plasmid in a Parkinson's disease model. Theranostics 2017; 7(2): 344-56. (SCI indexed, IF: 8.712) front cover article

https://www.ncbi.nlm.nih.gov/pubmed/28042339

10. Yang RC+, Wu LF+, Chen JH+, Chen WY, Zhang L, Zhang L, You R, Yin L, Li CH, Guan YQ*. Cell senescence regulation of HSC induced by three different chargeable biomaterials. ACS Appl Mater Interfaces 2016; 8(40): 26638-47. (SCI indexed, IF: 7.504)

http://pubs.acs.org/doi/10.1021/acsami.6b10377

11.  Chen WY, Yang RC, Wang HM, Zhang L, Hu KK, Li CH, You R, Yin L, Guan YQ*. Self-assembled heterojunction carbon nanotubes synergizing with photoimmobilized IGF-1 inhibit cellular senescence. Adv Healthc Mater 2016; 5(18): 2413-26. (SCI indexed, IF: 5.110)

http://onlinelibrary.wiley.com/doi/10.1002/adhm.201600359/full

12. Wu LF+, Hu KK+, Zhang L, Chen WY, Chen XH, You R, Yin L, Guan YQ*. Preparation and characterization of latex films photo-immobilized with IFN-α. Colloid Surface B 2016; 145: 104-13. (SCI indexed, IF: 3.887) cover invited

http://www.sciencedirect.com/science/article/pii/S092777651630306X

13. Zhang LK, Cai WW, Chen WY, Zhang L, Hu KK, Guan YQ*. Synthesis of AzPhchitosan-bifenthrin-PVC to protect cables against termites. Carbohyd Polym 2016; 139: 50-60. (SCI indexed, IF: 4.811)

http://www.sciencedirect.com/science/article/pii/S0144861715011650

14. Zhan XY, Guan YQ*. Design of magnetic nanoparticles for hepatocellular carcinoma treatment using the control mechanisms of the cell internal nucleus and external membrane. J Mater Chem B 2015; 3(20): 4191-204. (SCI indexed, IF: 4.543)

http://pubs.rsc.org/en/content/articlelanding/2015/tb/c5tb00514k#!divAbstract

15. Li ZB, Guan YQ*, Liu JM*. The role of STAT-6 as a key transcription regulator in HeLa cell death induced by IFN-γ/TNF-α co-immobilized on nanoparticles. Biomaterials 2014; 35(18): 5016-27. (SCI indexed, IF: 8.402)

http://www.sciencedirect.com/science/article/pii/S0142961214002245

16. Guan YQ, Zheng Z, Huang Z, Li ZB, Niu SQ, Liu JM*. Powerful inner/outer controlled multi-target magnetic nanoparticle drug carrier prepared by liquid photo-immobilization. Sci Rep-UK 2014; 4: 4990-8. (SCI indexed, IF: 4.259)

https://www.nature.com/articles/srep04990

17. Guan YQ+, Li ZB+, Yang AN, Huang Z, Zheng Z, Zhang L, Li L, Liu JM*. Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-a plus IFN-γ on polystyrene and the role of p53 activation. Biomaterials 2012; 33(26): 6162-71. (SCI indexed, IF: 8.402)

http://www.sciencedirect.com/science/article/pii/S0142961212005789

18. Guan YQ+, Zheng Z+, Liang LH, Li ZB, Zhang L, Du JJ, Liu JM*. The apoptosis of OVCAR-3 induced by TNF-a plus IFN-γ co-immobilized polylactic acid copolymers. J Mater Chem 2012; 22(29): 14746-55. (SCI indexed, IF: 6.626)

http://pubs.rsc.org/en/Content/ArticleLanding/2012/JM/c2jm31972a#!divAbstract

19. Guan YQ+, Zheng Z+, Li ZB, Liu JM*. Cell death in HeLa mediated by thermoplastic polyurethane with co-immobilized IFN-γ plus TNF-α. Acta Biomater 2012; 8(3): 1348-56. (SCI indexed, IF: 6.319)

http://www.sciencedirect.com/science/article/pii/S1742706111005265

20. Guan YQ, Chen JM, Li ZB, Feng QL, Liu JM*. Immobilisation of bifenthrin for termite control. Pest Manag Sci 2011; 67(2): 244-251 (SCI indexed, IF: 3.253)

http://onlinelibrary.wiley.com/doi/10.1002/ps.2065/full

21. Guan YQ, Chen JM, Tang JH, Yang Le, Liu JM*. Immobilizing bifenthrin on wood for termite control. Int Biodeter Biodegr 2011; 65(3): 389-395. (SCI indexed, IF:2.962)

http://www.sciencedirect.com/science/article/pii/S0964830511000059

22. Guan YQ, Li ZB, Chen JM, Tao HM, Wang WW, Zheng Z Li L, Liu JM*. Pathway of programmed cell death in HeLa cells induced by polymeric anti-cancer drugs. Biomaterials 2011; 32(14): 3637-46. (SCI indexed, IF: 8.402)

http://www.sciencedirect.com/science/article/pii/S0142961211001062

23. Guan YQ, Li ZB, Wang X, Ni YL, Yang AN, Liu JM*. Synthesis of a kind of temperature-responsive cell culture surface for corneal sheet. J Mater Sci Technol 2010; 26(12): 1119-1126 (SCI indexed, IF: 2.764)

http://www.sciencedirect.com/science/article/pii/S100503021160011X

24. Guan YQ+, Li ZB+, Liu JM*. Death signal transduction induced by co-immobilized TNF-a plus IFN-γ and the development of polymeric anti-cancer drugs. Biomaterials 2010; 31(34): 9074-85. (SCI indexed, IF: 8.402) http://www.sciencedirect.com/science/article/pii/S0142961210010823

 

  

  五、联系方式:

工作邮箱: guanyqscnu@163.com

本实验室招收博士后、博士生和硕士生,欢迎报读。

 

  六、科学网博客:

http://blog.sciencenet.cn/home.php?mod=space&uid=38667

 

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