高彩吉教授个人简介

博士，教授，博士生导师

研究方向：植物细胞生物学

E-mail：gaocaiji@m.scnu.edu.cn或者gaocaiji@163.com

地址：广州市天河区石牌华南师范大学生命科学学院409A

教育和工作经历

2016年3月 ~ 至今：华南师范大学生命科学学院（SCNU），教授（Principle Investigator）

2012年11月 ~ 2016年2月：香港中文大学 （CUHK），博士后研究员（Postdoctoral Researcher）

2012年7月 ~ 2012年10月：香港中文大学（CUHK），助理研究员（Research Assistant）

2008年8月 ~ 2012年6月：香港中文大学生命科学学院，生物学，博士

2005年9月 ~ 2008年6月：华南师范大学，光学（生物物理学方向），硕士

2001年9月 ~ 2005年7月：临沂大学，生物科学，本科

研究方向

以拟南芥和玉米为研究材料，立足植物细胞生物学研究热点和前沿问题，结合生化、分子细胞、遗传及各类组学手段重点开展如下研究：

l   植物细胞囊泡运输及其调控植物环境适应的分子机制

l   植物自噬及其调控植物环境适应的分子机理

l   泛素化蛋白分选及液泡介导的植物蛋白降解

主持项目和获得荣誉

l   霍英东教育基金会第十七届高等院校青年科学基金，2020-2022，主持人

l   国家自然基金面上项目：植物特有蛋白FS4调控细胞内吞作用和植物对硼元素吸收转运的分子机制研究，2019-2022，主持人

l   广东省普通高校特色创新类项目，2019-2021，主持人

l   国家自然基金面上项目：囊泡运输调控蛋白FREE1参与植物应答ABA和盐胁迫信号的分子机制研究，2017-2020，主持人

l   2018年教育部高等学校科学研究自然科学奖二等奖（第二获奖人）

l   2012年度香港中文大学生命科学学院研究生最佳研究论文奖

社会服务

中国植物生理与分子生物学会细胞与发育生物学专业委员会委员

广东省植物生理学会理事

《Frontiers in Plant Science》，Review Editor

《Plant Science》，Editorial board member

长期为《Plant Cell》，《Molecular Plant》，《Plant Physiology》，《New Phytologist》等国际主流植物学研究期刊审稿。

发表论文

Representative publications (^#co-first, *correspondence)

1.    Yang, C^#., Shen, W^#., Yang, L^#., Sun, Y., Li, X., Lai, M., Wei, J., Wang, C., Xu, Y., Li, F., Liang, S., Zhong, S., Luo, M*., and Gao, C*. (2020). HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation. Molecular Plant 13, 515-531.

2.    Li, H^#., Li, Y^#., Zhao, Q^#., Li, T., Wei, J., Li, B., Shen, W., Yang, C., Zeng, Y., Rodriguez, P.L., Zhao, Y., Jiang, L*., Wang, X*., and Gao, C*. (2019). The plant ESCRT component FREE1 shuttles to the nucleus to attenuate abscisic acid signalling. Nature Plants 5, 512-524.

3.    Zhao, Q^#*., Shen, J^#., Gao, C^#., Cui, Y., Wang, Y., Cui, J., Cheng, L., Cao, W., Zhu, Y., Huang, S., Zhou, Q., Leong, C.K., Leung, K.P., Chen, X., and Jiang, L*. (2019). RST1 Is a FREE1 Suppressor That Negatively Regulates Vacuolar Trafficking in Arabidopsis. Plant Cell 31, 2152-2168.

4.    Liu, C^#., Shen, W^#., Yang, C^#., Zeng, L., and Gao, C*. (2018). Knowns and unknowns of plasma membrane protein degradation in plants. Plant Science 272, 55-61.

5.    Gao, C^#., Zhuang, X^#., Shen, J^#., and Jiang, L*. (2017). Plant ESCRT Complexes: Moving Beyond Endosomal Sorting. Trends in Plant Science 22, 986-998.

6.    Shen, W., Xiao, Z., Shen, J., and Gao, C*. (2017). Analysis of Golgi-Mediated Protein Traffic in Plant Cells. Methods in Molecular Biology, 7262-7263_7266.

7.    Shen, J^#., Gao, C^#., Zhao, Q., Lin, Y., Wang, X., Zhuang, X., and Jiang, L. AtBRO1 Functions in ESCRT-I Complex to Regulate Multivesicular Body Protein Sorting. (2016). Molecular Plant. 9:760-763.

8.    Gao, C., Zhao, Q., and Jiang, L. (2015). Vacuoles protect plants from high magnesium stress. Proc Natl Acad Sci USA 112, 2931-2932.

9.    Gao, C^#., Zhuang, X^#., Cui, Y., Fu, X., He, Y., Zhao, Q., Zeng, Y., Shen, J., Luo, M., and Jiang, L. (2015b). Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation. Proc Natl Acad Sci USA 112, 1886-1891.

10.  Woo, C.H^#., Gao, C^#., Yu, P., Tu, L., Meng, Z., Banfield, D.K., Yao, X., and Jiang, L. (2015). Conserved function of the lysine-based KXD/E motif in Golgi retention for endomembrane proteins among different organisms. Molecular Biology of the Cell 26, 4280-4293.

11.  Gao, C., Luo, M., Zhao, Q., Yang, R., Cui, Y., Zeng, Y., Xia, J., and Jiang, L. (2014). A unique plant ESCRT component, FREE1, regulates multivesicular body protein sorting and plant growth. Current Biology 24, 2556-2563.

12.  Gao, C., Cai, Y., Zhuang, X., and Jiang, L. (2014). Analysis of prevacuolar compartment-mediated vacuolar proteins transport. Methods in Molecular Biology, 1420-1423_1429.

13.  Gao, C^#., Cai, Y^#., Wang, Y., Kang, B.H., Aniento, F., Robinson, D.G., and Jiang, L*. (2014). Retention mechanisms for ER and Golgi membrane proteins. Trends in Plant Science 19, 508-515.

14.  Cai, Y^#., Zhuang, X^#., Gao, C^#., Wang, X^#., and Jiang, L*. (2014). The Arabidopsis Endosomal Sorting Complex Required for Transport III Regulates Internal Vesicle Formation of the Prevacuolar Compartment and Is Required for Plant Development. Plant Physiology 165, 1328-1343.

15.  Gao, C., Yu, C.K., Qu, S., San, M.W., Li, K.Y., Lo, S.W., and Jiang, L. (2012). The Golgi-localized Arabidopsis endomembrane protein12 contains both endoplasmic reticulum export and Golgi retention signals at its C terminus. Plant Cell 24, 2086-2104.

Other publications

16.  Zhu, D., Zhang, M., Gao, C., and Shen, J. (2020). Protein trafficking in plant cells: Tools and markers. Science China Life Science 63, 343-363.

17.  Wang, X^#*., Xu, M^#., Gao, C., Zeng, Y., Cui, Y., Shen, W*., and Jiang, L. (2020). The roles of endomembrane trafficking in plant abiotic stress responses. Journal of Integrative Plant Biology 62, 55-69.

18.  Ge, C^#., Gao, C^#., Chen, Q., Jiang, L., and Zhao, Y*. (2019). ESCRT-dependent vacuolar sorting and degradation of the auxin biosynthetic enzyme YUC1 flavin monooxygenase. Journal of Integrative Plant Biology 61, 968-973.

19.  Cui, Y., Cao, W., He, Y., Zhao, Q., Wakazaki, M., Zhuang, X., Gao, J., Zeng, Y., Gao, C., Ding, Y., Wong, H.Y., Wong, W.S., Lam, H.K., Wang, P., Ueda, T., Rojas-Pierce, M., Toyooka, K., Kang, B.H., and Jiang, L. (2019). A whole-cell electron tomography model of vacuole biogenesis in Arabidopsis root cells. Nature Plants 5, 95-105.

20.  Huang, X., Zheng, C., Liu, F., Yang, C., Zheng, P., Lu, X., Tian, J., Chung, T., Otegui, M.S., Xiao, S., Gao, C., Vierstra, R.D., and Li, F. (2019). Genetic Analyses of the Arabidopsis ATG1 Kinase Complex Reveal Both Kinase-Dependent and Independent Autophagic Routes during Fixed-Carbon Starvation. Plant Cell 31, 2973-2995.

21.  Yang, C., Shen, W., Chen, H., Chu, L., Xu, Y., Zhou, X., Liu, C., Chen, C., Zeng, J., Liu, J., Li, Q., Gao, C., Charron, J.B., and Luo, M. (2018). Characterization and subcellular localization of histone deacetylases and their roles in response to abiotic stresses in soybean. BMC Plant Biology 18, 018-1454.

22.  Shen, J., Zhao, Q., Wang, X., Gao, C., Zhu, Y., Zeng, Y., and Jiang, L. (2018). A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis. Nature Communications 9, 018-05913.

23.  Lui, N.C., Tam, W.Y., Gao, C., Huang, J.D., Wang, C.C., Jiang, L., Yung, W.H., and Kwan, K.M. (2017). Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin. Nature Communications 8.

24.  Gimeno-Ferrer, F., Pastor-Cantizano, N., Bernat-Silvestre, C., Selvi-Martinez, P., Vera-Sirera, F., Gao, C., Perez-Amador, M.A., Jiang, L., Aniento, F., and Marcote, M.J. (2017). alpha2-COP is involved in early secretory traffic in Arabidopsis and is required for plant growth. Journal of Experimental Botany 68, 391-401.

25.  Cui, Y., Zhao, Q., Xie, H.T., Wong, W.S., Wang, X., Gao, C., Ding, Y., Tan, Y., Ueda, T., Zhang, Y., and Jiang, L. (2017). MONENSIN SENSITIVITY1 (MON1)/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)-Mediated Rab7 Activation Regulates Tapetal Programmed Cell Death and Pollen Development. Plant Physiology 173, 206-218.

26.  Zhuang, X., Chung, K.P., Cui, Y., Lin, W., Gao, C., Kang, B.H., and Jiang, L. (2017). ATG9 regulates autophagosome progression from the endoplasmic reticulum in Arabidopsis. Proc Natl Acad Sci USA 114, E426-E435.

27.  Tan, X., Cao, K., Liu, F., Li, Y., Li, P., Gao, C., Ding, Y., Lan, Z., Shi, Z., Rui, Q., Feng, Y., Liu, Y., Zhao, Y., Wu, C., Zhang, Q., Jiang, L., and Bao, Y. (2016). Arabidopsis COG Complex Subunits COG3 and COG8 Modulate Golgi Morphology, Vesicle Trafficking Homeostasis and Are Essential for Pollen Tube Growth. PLoS Genetics 12.

28.  Sancho-Andres, G., Soriano-Ortega, E., Gao, C., Bernabe-Orts, J.M., Narasimhan, M., Muller, A.O., Tejos, R., Jiang, L., Friml, J., Aniento, F., and Marcote, M.J. (2016). Sorting Motifs Involved in the Trafficking and Localization of the PIN1 Auxin Efflux Carrier. Plant Physiology 171, 1965-1982.

29.  Cui, Y., Shen, J., Gao, C., Zhuang, X., Wang, J., and Jiang, L. (2016). Biogenesis of Plant Prevacuolar Multivesicular Bodies. Molecular Plant 9, 774-786.

30.  Belda-Palazon, B., Rodriguez, L., Fernandez, M.A., Castillo, M.C., Anderson, E.M., Gao, C., Gonzalez-Guzman, M., Peirats-Llobet, M., Zhao, Q., De Winne, N., Gevaert, K., De Jaeger, G., Jiang, L., Leon, J., Mullen, R.T., and Rodriguez, P.L. (2016). FYVE1/FREE1 Interacts with the PYL4 ABA Receptor and Mediates Its Delivery to the Vacuolar Degradation Pathway. Plant Cell 28, 2291-2311.

31.  Zhao, Q., Gao, C., Lee, P., Liu, L., Li, S., Hu, T., Shen, J., Pan, S., Ye, H., Chen, Y., Cao, W., Cui, Y., Zeng, P., Yu, S., Gao, Y., Chen, L., Mo, B., Liu, X., Xiao, S., Zhao, Y., Zhong, S., Chen, X., and Jiang, L. (2015). Fast-suppressor screening for new components in protein trafficking, organelle biogenesis and silencing pathway in Arabidopsis thaliana using DEX-inducible FREE1-RNAi plants. Journal of Genetics and Genomics 42, 319-330.

32.  Zhuang, X., Cui, Y., Gao, C., and Jiang, L. (2015). Endocytic and autophagic pathways crosstalk in plants. Current Opinion in Plant Biology 28, 39-47.

33.  Zeng, Y., Chung, K.P., Li, B., Lai, C.M., Lam, S.K., Wang, X., Cui, Y., Gao, C., Luo, M., Wong, K.B., Schekman, R., and Jiang, L. (2015). Unique COPII component AtSar1a/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana. Proc Natl Acad Sci USA 112, 14360-14365.

34.  Cui, Y., Zhao, Q., Gao, C., Ding, Y., Zeng, Y., Ueda, T., Nakano, A., and Jiang, L. (2014). Activation of the Rab7 GTPase by the MON1-CCZ1 Complex Is Essential for PVC-to-Vacuole Trafficking and Plant Growth in Arabidopsis. Plant Cell 26, 2080-2097.

35.  Shen, J., Ding, Y., Gao, C., Rojo, E., and Jiang, L. (2014). N-linked glycosylation of AtVSR1 is important for vacuolar protein sorting in Arabidopsis. Plant Journal 80, 977-992.

36.  Meng, W., Hsiao, A.S., Gao, C., Jiang, L., and Chye, M.L. (2014). Subcellular localization of rice acyl-CoA-binding proteins (ACBPs) indicates that OsACBP6::GFP is targeted to the peroxisomes. New Phytologist 203, 469-482.

37.  Ma, X., Chen, Z., Hua, D., He, D., Wang, L., Zhang, P., Wang, J., Cai, Y., Gao, C., Zhang, X., Zhang, F., Wang, T., Hong, T., Jin, L., Qi, X., Chen, S., Gu, X., Yang, D., Pan, Q., Zhu, Y., Chen, Y., Chen, D., Jiang, L., Han, X., Zhang, Y., Jin, J., and Yao, X. (2014). Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc Natl Acad Sci USA 111, 6389-6394.

38.  Zhuang, X., Wang, H., Lam, S.K., Gao, C., Wang, X., Cai, Y., and Jiang, L. (2013). A BAR-domain protein SH3P2, which binds to phosphatidylinositol 3-phosphate and ATG8, regulates autophagosome formation in Arabidopsis. Plant Cell 25, 4596-4615.

39.  Jia, T., Gao, C., Cui, Y., Wang, J., Ding, Y., Cai, Y., Ueda, T., Nakano, A., and Jiang, L. (2013). ARA7(Q69L) expression in transgenic Arabidopsis cells induces the formation of enlarged multivesicular bodies. Journal of Experimental Botany 64, 2817-2829.

40.  Cai, Y., Zhuang, X., Wang, J., Wang, H., Lam, S.K., Gao, C., Wang, X., and Jiang, L. (2012). Vacuolar degradation of two integral plasma membrane proteins, AtLRR84A and OsSCAMP1, is cargo ubiquitination-independent and prevacuolar compartment-mediated in plant cells. Traffic 13, 1023-1040.

41.  Cai, Y., Jia, T., Lam, S.K., Ding, Y., Gao, C., San, M.W., Pimpl, P., and Jiang, L. (2011). Multiple cytosolic and transmembrane determinants are required for the trafficking of SCAMP1 via an ER-Golgi-TGN-PM pathway. Plant Journal 65, 882-896.

42.  Zhang, L., Xu, Q., Xing, D., Gao, C., and Xiong, H. (2009). Real-time detection of caspase-3-like protease activation in vivo using fluorescence resonance energy transfer during plant programmed cell death induced by ultraviolet C overexposure. Plant Physiology 150, 1773-1783.

43.  Zhang, L., Li, Y., Xing, D., and Gao, C. (2009). Characterization of mitochondrial dynamics and subcellular localization of ROS reveal that HsfA2 alleviates oxidative damage caused by heat stress in Arabidopsis. Journal of Experimental Botany 60, 2073-2091.

44.  Gao, C., Zhang, L., Wen, F., and Xing, D. (2008). Sorting out the role of reactive oxygen species during plant programmed cell death induced by ultraviolet-C overexposure. Plant Signal Behav 3, 197-198.

45.  Gao, C., Xing, D., Li, L., and Zhang, L. (2008). Implication of reactive oxygen species and mitochondrial dysfunction in the early stages of plant programmed cell death induced by ultraviolet-C overexposure. Planta 227, 755-767.

欢迎对植物分子细胞生物学感兴趣的同学及博后和青年英才等加入本实验室！