李海航教授个人简介

李海航

博士，教授，博士生导师

联系方式

邮件：广州市石牌华南师范大学生命科学学院新楼525室

电话/传真: 020-8521-2630, Email: li_haihang@yahoo.com

研究领域: 植物化学与分子生物学

研究方向: 天然与生化药物

研究课题

天然与生化药物筛选与分离制备

功能蛋白结构与活性及基因工程表达

生物资源综合开发利用

工作经历

2005年 - 现在： 华南师范大学生命科学学院教授

1997年-2004年：加拿大林山食品有限公司技术经理

1995年-1996年：美国罗斯夫肿瘤研究所博士后研究员

1993年-1994年：日本理化学研究所国际尖端研究系统研究员

1992年-1993年：东京大学分子与细胞生物学研究所研究员

1989年-1992年：日本科学技术事业团(现日本科学技术振兴机构)研究员

1987年-1988年：日本鹿儿岛大学访问学者

1982年-1984年：中南林业科技大学植物生理生化教师

学术兼职

广东省植物学会理事

广东省药学会制药工程专业委员会副主任委员、靶向药物研究专题组组长

Hans Journal of   Botanical Research, Medicinal & Aromatic Plants, European Journal of Medicinal Plants 编辑

近年发表的主要论文 (*corresponding author)

62) Chen R, Wang XJ, Zhang YY, Xing Y, Yang Y, Ni H, Li HH (李海航)*. 2019. Simultaneous extraction and separation of oil, proteins, and glucosinolates from Moringa oleifera seeds. Food Chemistry, 300, doi.org/10.1016/j.foodchem.2019.125162. SCI 5.399 (顶级期刊)

61) Yang L, Xi Y, Luo XY, Ni H, Li HH (李海航)*. 2019. Preparation of peroxidase and phenolics using discarded sweetpotato old stems. Scientific Reports, 9(1): 3769, DOI: 10.1038/s41598-019-40568-9 SCI 4.122

60) Ma LL, Kaneko G, Wang XJ, Xie J, Tian JJ, Zhang K, Wang GJ, Yu DC, Li ZF, Gong WB, Yu EM∗, Li HH (李海航)*. 2019. Effects of four faba bean extracts on growth parameters, textural quality, oxidative responses, and gut characteristics in grass carp. Aquaculture, 516 (2020) 734620. Doi.org/10.1016/j.aquaculture.2019.734620. SCI IF 3.42

59) Ni H*, Hays H, Stead D, Liu G, Yang J, Li HH (李海航), Raikos V. 2019. Interaction of whey protein with polyphenols from salal fruits (Gaultheria shallon) and the effects on protein structure and hydrolysis pattern by flavourzyme. International Journal of Food Science and Technology, doi:10.1111/ijfs.14394. SCI IF 2.281

58) Lin L, Zhang YY, Chen R, Yang L, Ni H, Li HH (李海航)*. 2019. Highly simplified preparation of tea flavonoids from surplus tea leaves by the novel three-phase extraction and purification. Separation Science & Technology, 54(5): 741-746. SCI, 1.20

57) Li QR, Luo JL, Zhou ZH, Wang GY, Chen R, Cheng S, Wu M, Li H, Ni H, Li HH (李海航)*. 2018. Simplified recovery of enzymes and nutrients in sweet potato wastewater and preparing health black tea and theaflavins with scrap tea. Food Chemistry, 254: 854-862. SCI IF 4.946 (顶级期刊)

56) Ni H, Hao RL, Li XF, Raikos V, Li HH (李海航). 2018. Synergistic anticancer and antibacterial activities of cordycepin and selected natural bioactive compounds. Tropical Journal of Pharmaceutical Research, 17 (8): 1621-1627. SCI

55) Li QR, Wu M, Huang RJ, Chen YF, Chen CJ, Li H, Ni H, Li HH (李海航)*. 2017. Extraction and preparation of high-aroma and low-caffeine instant green teas by the novel column chromatographic extraction method with gradient elution. Journal of Food Science and Technology, 2017, 54(7): 2186–2192. SCI 1.797

54) Ni H, Fan XM, Guo HN, Liang JH, Li QR, Yang L, Li H, Li HH (李海航)*. 2017. Comprehensive Utilization of Activated Sludge for Preparation of Hydrolytic Enzymes, Polyhydroxyalkanoates and Water-Retaining Organic Fertilizer. Preparative Biochemistry & Biotechnology, 47(6): 611-618. SCI IF 1.361

53) Ni H, Guo PC, Jiang WL, Fan XM, Luo XY, Li HH (李海航)*. 2016. Expression of nattokinase in Escherichia coli and renaturation of its inclusion body. Journal of Biotechnology, 231: 65–71. SSN: 0168-1656. SCI IF 2.599

52) Ni H, Li YH, Wu SS, Hao RL, Li HH (李海航)*. 2016. Identification of adenosine deaminase inhibitors from Tofu wastewater and litchi shell and their synergistic anticancer and antibacterial activities with cordycepin. International Journal of Food Science & Technology, 51(5): 1168-1176. SCI 1.640

51) Dong W, Niu L, Li HH (李海航), Gao F. 2016. Isolation and analysis of the promoter of IbMYB1 gene from storage roots of purple-fleshed sweet potato. Journal of Plant Biochemistry and Biotechnology, 25(3):278–284. SCI IF 0.954

50) Hu M, Lu Z, Guo J, Luo Y, Li H (李海航), Li L, Gao F. 2016. Cloning and characterization of the cDNA and promoter of UDP-glucose: flavonoid 3-O-glucosyltransferase gene from a purple-fleshed sweet potato. South African Journal of Botany 106: 211-220. SCI IF 1.427

49) Zhang YW, Fan WW, Li H, Ni H, Han HB, Li HH (李海航)*. 2015. Simultaneous column chromatographic extraction and purification of abscisic acid in peanut plants for direct HPLC analysis. Journal of Chromatography B, 1002: 277-284. SCI 2.603

48) Hu RS, Wang J, Li H, Chen YF, Zhang YW, Xiang AP, Ni H, Li HH (李海航)*. 2015. Simultaneous extraction of nicotine and solanesol from waste tobacco materials by the column chromatographic extraction method and their separation and purification. Separation and Purification Technology, 146: 1-7. SCI IF 3.359

47) Cheng S, Zhang YF, Zeng ZQ, Lin J, Zhang YW, Ni H, Li HH (李海航)*. 2015. Screening, separating and completely recovering polyphenol oxidases and other biochemicals from sweet potato wastewater in starch production. Applied Microbiology and Biotechnology, 99(4): 1745-1753. SCI IF 3.420（顶级期刊)

46) Guo J, Zhou W, Lu Z, Li H, Li HH(李海航), Gao F. 2015. Isolation and Functional Analysis of Chalcone Isomerase Gene from Purple-Fleshed Sweet Potato. Plant Molecular Biology Report 33:1451–1463. SCI IF 1.932

45) Yi ZL, Huang WF, Ren Y, ONAC E, Zhou GF, Peng S, Wang XJ, Li HH (李海航)*. 2014. LED lights increase bioactive substances at low energy costs in culturing fruiting bodies of Cordyceps militaris. Scientia Horticulturae, 175: 139–143. SCI IF 1.624

44) Zheng H, Li JL, Li HH (李海航), Hu GC, Li HS. 2014. Analysis of Trace Metals and Perfluorinated Compounds in 43 Representative Tea Products from South China. Journal of Food Science, 79(6):C1123-9. doi: 10.1111/1750-3841.12470. SCI IF 1.815

43) Yao LH, Meng W, Song RF, Xiong QP, Sun W, Luo ZQ, Yan WW, Li YP, Liu XP, Li HH (李海航), Xiao P. 2014. Modulation effects of cordycepin on the skeletal muscle contraction of toad gastrocnemius muscle. European Journal of Pharmacology, 726: 9-15. SCI IF 2.896

42) Han HB, Li H, Hao RL, Chen YF, Ni H, Li HH (李海航)*. 2014. One-step column chromatographic extraction with gradient elution followed by automatic separation of volatiles, flavonoids and polysaccharides from Citrus grandis. Food Chemistry, 145： 542-548. SCI IF 4.529（顶级期刊）

41) Zeng XH, Li YH, Wu SS, Hao RL, Li H, Ni H, Han HB, Li HH (李海航)*. 2013. New and highly efficient column chromatographic extraction and simple purification of camptothecin from Camptotheca acuminata and Nothapodytes pittospoides. Phytochemical Analysis, 24(6): 623–630. SCI IF 2.293

40) Yao LH, Huang JN, Li CH, Li HH (李海航), Yan WW, Cai AL, Liu WX, Xiao P*. 2013. Cordycepin suppresses excitatory synaptic transmission in rat hippocampal slices via a presynaptic mechanism. CNS Neuroscience & Therapeutics, 19(4): 216-221. SCI 3.919

39) Cai ZL, Wang CY, Jiang ZJ, Li HH (李海航), Liu WX, Gong LW, Xiao P*, Li CH*. 2013. Effects of cordycepin on Y-maze learning task in mice. European Journal of Pharmacology, 714(1–3): 249-253. SCI 2.896

38) Wang L, Gong LH, Chen CJ, Han HB, Li HH (李海航)*. 2012. Column chromatographic extraction and separation of polyphenols, caffeine and theanine from green tea. Food Chemistry, 131: 1539–1545. SCI IF 4.529（顶级期刊）

37) Pan LP, Yu SL, Chen CJ, Li H, Wu YL, Li HH (李海航)*. 2012. Cloning a peanut resveratrol synthase gene and its expression in purple sweet potato. Plant Cell Reports, 31(1): 121-131. SCI IF 2.869

36) Li HH (李海航)*. 2012. Li HH. 2012. Editorial Message to the Journal of Medicinal & Aromatic Plants. Medicinal Aromatic Plants, 1:e115. doi:10.4172/map.1000e115.

35) Ni H, Li L, Guo SS, Li HH (李海航), Jiang R, Hu SQ*. 2012. Isolation and Identification of an Angiotensin-I Converting Enzyme Inhibitory Peptide from Yeast (Saccharomyces cerevisiae). Current Analytical Chemistry, 8(1): 180-185. SCI IF 1.306

34) Li HH (李海航)*, Hao RL, Wu SS, Guo PC, Chen CJ, Pan LP, Ni H. 2011. Occurrence, function and potential medicinal applications of the phytohormone abscisic acid in animals and humans. Biochemical Pharmacology, 82(7): 701-712. SCI IF 4.581（顶级期刊）

33) Zhan PY, Zeng XH, Zhang HM, Li HH (李海航)*. 2012. High-efficient column chromatographic extraction of curcumin from Curcuma longa. Food Chemistry, 129(2): 700-703. SCI IF 4.529（顶级期刊）

32) Liu SR, Guo PC, Li HH (李海航)*. 2011. Synthesis of a potato starch-based concentrating polymer and its application in the concentration of extraction solutions. Carbohydrate Polymers, 84(1): 560–565. SCI IF 4.811（顶级期刊）

31) Zhou WL, Wang YH, Chen G, Lü M, Yang LX, Hu XX, Li HH (李海航), Li L*. 2011. Cloning of a gene encoding glycosyltransferase from Pueraria lobata (Wild.) Ohwi and its expression in Pichia pastoris. African Journal of Biotechnology, 10: 85-96.

30) Wu YL, Pan LP, Yu SL, Li HH (李海航)*. 2010. Cloning, microbial expression and structure-activity relationship of polyphenol oxidase genes from Camellia sinensis. Journal of Biotechnology, 145(1): 66-72. SCI 2.599

29) Zhang ZY, Pan LP, Li HH (李海航)*. 2010. Isolation, identification and characterization of soil microbes which degrade phenolic allelochemicals. Journal of Applied Microbiology, 108(5): 1839-1849, SCI IF 2.099

28) Ni H, Zhou XH, Li HH (李海航)*, Huang WF. 2009. Column chromatographic extraction and preparation of cordycepin from Cordyceps militaris waster medium. Journal of Chromatography B, 877(22): 2135–2141. SCI 2.603

27) Lu S, Su W, Li HH (李海航), Guo Z*. 2009. Abscisic acid improves drought tolerance of triploid bermudagrass and involves H₂O₂- and NO-induced antioxidant enzyme activities. Plant Physiology and Biochemistry, 47(2): 132-138. SCI IF 2.724

26) Lu S, Chen C, Wang Z, Guo Z*, Li HH (李海航). 2009. Physiological responses of somaclonal variants of triploid bermudagrass (Cynodon transvaalensis X Cynodon dactylon) to drought stress. Plant Cell Reports, 28(3): 517-526. SCI IF 2.869

25) Liang J, Yang L, Chen X, Li L*, Guo D, Li HH (李海航), Zhang B. 2009. Cloning and characterization of the promoter of 9-cis-epoxycarotenoid dioxygenase gene in Arachis hygogaea L. Bioscience, Biotechnology and Biochemistry, 72(9): 2103-2106. SCI IF 1.3

24) Lu S, Wang Z, Niu Y, Chen Y, Chen H, Fan Z, Lin J, Yan K, Guo Z*, Li HH (李海航). 2009. Gamma-ray radiation induced dwarf mutants of turf-type bermudagrass. Plant Breeding, 128(2): 205-209. SCI 1.335

23) Yang L, Liang J, Li HH (李海航), Li L*. 2009. Cloning and expression analysis of an aldehyde oxidase gene in Arachis hygogaea L. J. Environmental Biology, 30: 93-98. SCI IF 0.697

22) Ni H, Li L, Li HH (李海航)*. 2009. Tourmaline ceramic balls stimulate growth and metabolism of three fermentation microorganisms. World Journal of Microbiology and Biotechnology,, 24(5): 725-731. SCI IF 1.658

21) Wu B, Ni H, Li L, Li HH (李海航)*. 2009. SPE-HPLC quantification of curcumin in different cultivars and organs of ginger, Zingiber officinale Roscoe. Natural Products Research and Development, 20(5): 859-862.

20) Li HH (李海航)*, Gong LH, Zhang ZY, Wu YL, Li L. 2009. Degradation of allelochemicals in bamboo soil by hydrogen peroxide. J. Tropical and Subtropical Botany, 15(6): 513-520.

19) 吕琪，张耀元，倪贺，李海航. 2019. 八角中茴香油与莽草酸的提取和分离纯化. 华南师范大学学报(自然科学版),51( 2) : 69-75.

18) 李青嵘; 罗嘉玲; 程实; 倪贺; 李海航. 2018. 甘薯淀粉加工废水中生化成分回收的新方法研究. 华南师范大学学报(自然科学版)，50( 2): 57-64.

17) 罗嘉玲, 李青嵘, 张雅文, 陈亚飞, 倪贺, 李海航. 2018. 柱层析提取法提取青蒿素的工艺研究. 华南师范大学学报(自然科学版)，50(2): 65－69.

16) 林彩霞, 杨静蕊, 王光瑛, 倪贺, 李海航. 2017. 多酚氧化酶催化合成茶黄素研究. 植物生理学报, 53 (8): 1359–1364.

15) 李慧，张雅文，罗翔宇，赖天斌，李海航*. 2017. 人工养殖鳄鱼油的提取与精制工艺研究. 华南师范大学学报(自然科学版), 49(6): 71-76.

14) 周仲华，张达，倪贺*，李海航. 2017. 生物信息学法筛选催化茶黄素合成的天然多酚氧化酶. 华南师范大学学报(自然科学版), 49(3), 59-67.

13) 刘峻熙，李慧，倪贺*，李海航.2017. 除味啤酒酵母提取物的护肤功效研究. 现代食品科技, 33(8): 1-6.

12) 罗依雨，罗维，刘峻熙，杨志民，倪贺*，李海航.2016. 啤酒废酵母自溶提取物的制备及抗氧化活性研究. 华南师范大学学报(自然科学版), 48(1): 89－93.

11) 韩寒冰*，王明阳，刘杰凤，马超，李海航. 2015. 水蒸气蒸馏与乙醇提取化橘红叶成分的GC- MS分析. 食品研究与开发, 36 (11): 117-136.

10) 韩寒冰，李海航*，曾祥有，赵俊生. 2014. 化橘红果实生长发育过程中类黄酮的动态变化. 植物学报，49 (4): 424–431.

9) 韩寒冰*，王明阳，马超，李海航. 2014. HPLC-DAD和UPLC-MS/MS对蔓花生中二苯乙烯类化合物的研究. 天然产物研究与开发，26（5）: 699-703, 712.

8) 李海航*，罗嘉玲，倪贺. 2014. 鳄鱼资源开发和生物活性物质研究进展. 华南师范大学学报（自然科学版）46(3): 10-17.

7) 韩寒冰，沈兰，李海航*. 2014. 花生废弃物中白藜芦醇和白藜芦醇苷的提取与分析. 华南师范大学学报（自然科学版）, 46(1): 46-50.

6) 蔡昭林，李楚华，王晓琦，蒋中娇，郑月，李海航，肖鹏*. 2012. 虫草素改善脑缺血小鼠学习记忆及对海马神经元数量的影响. 华南师范大学学报( 自然科学版), 44(3): 95-99.

5) 李海航*, 林佳，曾广翔，凡薇薇. 2011. 植物激素脱落酸的药理作用与药用前景. 华南师范大学学报（自然科学版）, 2011(2): 7-12.

4) 欧阳振,邱杨,吴嘉妮,余瑶章,龚莉红,李海航*.2009.几种天然材料对茶多酚和咖啡因的吸附与分离特性.科技导报, 27(8): 64-68.

3) 潘丽萍,余丝莉,李海航*.2009.变味蛋白神秘果素的研究.科技导报,27(3): 99-101.

2) 倪贺,李海航*,黄文芳,李玲.2009.核糖核苷酸还原酶研究.科技导报,26(8): 79-83.

1)      黄城贵,潘丽萍,李海航*,李玲.2009.电气石对绿豆培养细胞生长的影响.生物技术,18(3): 61-63.

申请发明专利

1.       李海航. 植物功能成分层析提取新方法. 发明专利申请号 200810026061.X.

2.       李海航. 高效节能的高纯度虫草素提取与生产方法. 专利申请号 200910036611.0.

3.       李海航，张屹峰，林佳，曾昭钦，程实，倪贺. 从甘薯的水溶性提取液中分离和制备多酚氧化酶、β-淀粉酶和储藏蛋白的方法. 发明专利申请号201310194899.0.

4.       李海航, 林佳, 刘洁, 倪贺. 从甘薯的茎和叶中提取和制备过氧化物酶的方法. 发明专利申请号201310268803.0.

5.       李海航, 倪贺, 陈方媚, 范晓敏. 从水浮莲根中提取和制备蛋白酶的方法. 发明专利申请号201310241578.1.

6.       李海航，范晓敏，郭濠宁，倪贺. 活性污泥的高效利用方法. 发明专利申请号201310365379.1.

7.       李海航, 张雅文, 李慧, 罗翔宇, 倪贺. 鳄鱼油的制备方法. 发明专利申请号201510640867.8.

8.       李海航,黄瑞洁, 吴敏, 陈亚飞, 李慧, 倪贺. 高香速溶茶及其制备方法. 发明专利申请号201510642389.4.

9.       倪贺，刘俊熙，李海航,李慧，王光瑛. 酵母提取物的去味方法和酵母味成分的鉴定方法。发明专利申请号201610807829.1.

10.   倪贺，张志鹏，李海航，张耀元，席毅。分离纯化血竭素的方法. 发明专利申请号201611079032.0.

11.   倪贺，张志鹏，李海航，张耀元，席毅。制备药用血竭素提取物的方法。发明专利申请号.

12.      李海航，林丽，倪贺。一种简单高效的双液相提取、分离纯化和制备高纯度茶多酚的方法. 发明专利申请号201711140613.5.

获授权的发明专利

李海航. 2011. 高效节能的高纯度虫草素提取与生产方法. 发明专利号 ZL 200910036611.0.

李海航, 倪贺, 陈方媚, 范晓敏. 从水浮莲根中提取和制备蛋白酶的方法. 发明专利号CN 103320416 B.

李海航，张屹峰，林佳，曾昭钦，程实，倪贺. 从甘薯的水溶性提取液中分离和制备多酚氧化酶、β-淀粉酶和储藏蛋白的方法. 发明专利号ZL201310194899.0.

李海航，黄瑞洁，吴敏，陈亚飞，李慧，倪贺. 高香速溶茶及其制备方法。发明专利号ZL 2015 1 0642389.4.
倪贺，张志鹏，李海航. 分离纯化血竭素的方法，发明专利号2016110790320.