生命科学学院
School of Life Sciences
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2017-05-15 14:07:09 来源:华南师范大学生命科学学院 点击: 收藏本文
黄立华简介
博士,教授,硕士生导师 研究方向:昆虫变态发育的分子机理 联系方式:020-85210024 电子邮件:huanglh@scnu.edu.cn |
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个人简介 | |
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1994~1998年,本科就读于湖北农学院农学系,获学士学位。 1998~2001年,就读于南京农业大学昆虫学系,获硕士学位。 2001~2002年,在中国科学院动物研究所工作,任研究实习员。 2002~2004年,在沈阳化工研究院工作,任工程师。 2004~2007年,就读于中国科学院动物研究所,获理学博士学位(导师:康乐院士)。 2007~2009年,在美国康奈尔大学昆虫学系作博士后研究。 2010~2014年,华南师范大学生命科学学院副教授、硕士生导师。 2014.12至今:华南师范大学教授 | |
社会服务 |
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任中国昆虫学会和美国昆虫学会会员。先后担任多个刊物的审稿人,如Archives of Insect Biochemistry,Gene,Insect Science,Journal of Applied Entomology,Journal of Insect Science,Pest Management Science,Physiological Entomology,华南师范大学学报、昆虫学报、昆虫知识、中国农业科学等。 | |
研究兴趣 |
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研究兴趣:1. 昆虫变态发育的分子调控机理。昆虫在生长发育过程中通常要经历从幼虫发育为蛹,进而转变为成虫。在这两个变态过程中,昆虫体内发生着非常剧烈的变化:旧的组织和器官解体,新的组织和器官形成。这种变态是由昆虫保幼激素和蜕皮激素的分泌共同触发的。昆虫激素的分泌,本身受到一定的调控;同时,它还负责调节一系列早、晚期基因的表达,并最终产生变态反应。这种变态反应的分子机理是什么?这正是我们需要揭示的问题。同时,这一问题的阐明,对于寻找新的害虫防治靶标,有针对性地开发新的农药具有十分重要的指导意义。2. 昆虫中肠基因的功能解析。昆虫中肠担负着两种重要的功能:a. 营养物质的消化和吸收;b. 解毒代谢。我们课题组已经建立起了斜纹夜蛾中肠cDNA文库,并获得了大量的EST,如何解析这些中肠基因的功能,并将它们应用到害虫防治上是我们正致力于解决的问题。3. 昆虫变态发育过程中,各种代谢途径的变化及其调控。我们通过高通量测序已经获得了斜纹夜蛾的转录组数据,并通过DGE技术得到了这些基因在中肠、表皮和脂肪体不同发育阶段的表达谱。这些研究结果为我们进一步详细研究昆虫变态发育期糖、脂、蛋白质、氨基酸的代谢规律及其调控机制奠定了坚实的基础。3.转基因家蚕研究。通过转基因技术一方面研究丝腺发育调节相关基因的功能,另一方面可以改良家蚕品种,从而提高产丝量。 | |
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主持课题
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发表SCI文章: | |
1. Tong X.W., Chen, B., Huang, L.H.*,Feng, Q.L., Kang, L.* 2015. Proteomic analysis reveals that COP9 signalosome complex subunit 7A (CSN7A) is essential for the phase transition of migratory locust. Scientific Reports 5:12542. (IF:5.578) 2. Huang, L.X., Gong, Y.J.,Gu, J., Zeng, B.J., Huang, L.H.*, Feng, Q.L. 2015. Expression, subcellular localization and protein-protein interaction of four isoforms of EcR/USP in the common cutworm. Insect Science 22: 95-105 (IF: 1.786) 3. Shen, Y., Gong, Y.J., Gu, J., Huang, L.H.*, Feng. Q.L. 2014. Physiological effect of mild thermal stress and its induction of gene expression in the common cutworm, Spodoptera litura. J. Insect Physiol. 61: 34-41 (IF: 2.379) 4. Chen, W.J., Huang, L.X., Hu, D., Liu, L.Y., Gu, J., Huang, L.H.*, Feng, Q.L. 2014. Cloning, expression and chitin-binding activity of two peritrophin-like protein genes in the common cutworm, Spodoptera litura. Insect Science 21: 449-458. (IF: 1.786) 5. Gu, J., Huang, L.X., Gong, Y.J., Zheng, S.C., Liu, L., Huang, L.H*., Feng, Q.L. 2013. De novo characterization of transcriptome and gene expression dynamics in epidermis during the larval-pupal metamorphosis of common cutworm. Insect Biochemistry and Molecular Biology 43: 794-808 (IF: 3.234) 6. 罗婉冰,何文婧,黄玉秋,胡丹,黄立华*, 冯启理. 2013.斜纹夜蛾中肠糖代谢相关基因的克隆及mRNA表达分析. 昆虫学报 56(9): 965-973. 7. Gu, J., Huang, L.X., Shen, Y., Huang, L.H.*, Feng, Q.L. 2012. Hsp70 and small Hsps are the major heat shock protein members involved in midgut metamorphosis in the common cutworm, Spodoptera litura. Insect Molecular Biology 21(5): 535-543. (IF: 3.044) 8. Deng, H.M., Zhang, J.L., Li, Y., Zheng, S.C., Liu, L., Huang, L.H., Xu, W.H., Pallic, S.R., Feng, Q.L*. 2012. Homeodomain POU and Abd-A proteins regulate the transcription of pupal genes during metamorphosis of the silkworm, Bombyx mori. PNAS 109: 12598-12603 (http://www.pnas.org/content/109/31/12598). (IF: 9.737) 9. Zhang, X., Tiewsiri, K., Kain, W., Huang, L.H., Wang. P*. 2012. Resistance of Trichoplusia ni to Bacillus thuringiensis Toxin Cry1Ac Is Independent of Alteration of the Cadherin-Like Receptor for Cry Toxins. PLOS ONE 7(5):e35991 (IF: 3.73) 10.Rao, Z.C., He, W.Y., Liu, L., Zheng, S.C., Huang, L.H., Feng, Q.L. 2012. Identification, Expression and Target Gene Analyses of MicroRNAs in Spodoptera litura. PLOS ONE 7(5): e37730 (IF: 3.73) 11.Shen, Y., Gu, J., Huang, L.H*., Zheng, S.C., Liu, L., Xu, W.H., Feng, Q.L., Kang, L*. 2011. Cloning and expression analysis of six small heat shock protein genes in the common cutworm, Spodoptera litura. J Insect Physiol.57(7):1033-1044. (IF: 2.379) 12.Terenius, O., Papanicolaou, A., Garbutt, J.S., et al., Huang, L.H., et al. RNA interference in Lepidoptera: An overview of successful and unsuccessful studies and implications for experimental design. 2010. Journal of Insect Physiology 57: 231-245. (IF: 2.379) 13.Huang, L.H., Wang, C.Z., Kang, L. 2009. Cloning and expression of five heat shock protein genes in relation to cold hardening and development in the leafminer, Liriomyza sativa. Journal of Insect Physiology, 55: 279-285 (IF: 2.379). 14. Huang, L.H., Wang, H.S., Kang, L. 2008. Different evolutionary lineages of large and small heat shock proteins in Eukaryota. Cell Research, 18: 1074-1076 (IF: 10.526). 15.Huang, L.H., Kang, L. 2007. Cloning and inter-specific altered expression of heat shock protein genes in two leafminer species in response to thermal stress. Insect Molecular Biology, 16 (4): 491–500 (IF: 3.044). 16.Huang, L.H., Chen, B., Kang, L. 2007. Impact of mild temperature hardening on thermotolerance, fecundity, and Hsp gene expression in Liriomyza huidobrensis. Journal of Insect Physiology, 53 (12): 1199-1205 (IF: 2.379) 17.Wang, H.S., Wang, X.H., Zhou, C.S., Huang, L.H., Zhang, S.F., Guo, W., Kang, L. 2007. cDNA cloning of heat shock proteins and their expression in the two phases of the migratory locust. Insect Molecular Biology. 16: 207-219 (IF: 3.044). |