牛康康

时间：2024-03-11 15:42:00

牛康康-DNA高级结构

★ 姓名：牛康康

★ 职称：副教授

★ 学历：博士

★ 邮箱：kkniu@m.scnu.edu.cn

个人简介

牛康康，男，河南开封人。博士，副教授，硕士研究生导师。2019年6月毕业于华南师范大学生物化学与分子生物学专业，获理学博士学位。2019年7月入选国家“博士后创新人才支持计划”，留校从事博士后研究工作。2022年8月以“高层次人才-青年拔尖人才”留校工作，聘为副教授，硕士生导师。长期从事核酸G4和i-motif高级结构的鉴定、功能、形成机制和表观遗传调控机制研究，以第一作者或通讯作者在Nucleic Acids Research（2018，2019，2022）、Communications Biology（2021）、Epigenetics & Chromatin（2020）和Insect Biochemistry and Molecular Biology（2015）等国际期刊上发表学术论文数十篇。研究成果被Nature Reviews Molecular Cell Biology，Nature Chemistry，Nucleic Acids Research，Genome Biology等重要学术刊物文章多次引用。获国家博士后创新人才计划支持，主持国家自然科学基金面上项目、青年项目、博士后科学基金和广东省自然科学基金等科研项目多项。荣获第十届“中国昆虫学会青年科学技术奖”、广东省百名博士博士后创新人物等荣誉。

研究方向

1、核酸高级结构的鉴定、功能和表观遗传调控机制解析。

2、新型药物及其核酸作用靶点的鉴定。

主持科研项目

1、国家自然科学基金面上项目，2024.1-2027.12，主持。

2、华南师范大学高层次人才启动经费，2022-2027，主持

3、国家博士后创新人才支持计划，2019.7-2022.7，主持。

4、国家自然科学基金青年项目，2021.1-2023.12，主持。

5、中国博士后科学基金面上项目，2019.7-2022.7，主持。

6、广东省基础与应用基础研究基金青年基金，2021.1-2022.12，主持。

代表性论文

1. Kangkang Niu, Xiaojuan Zhang, Huimin Deng, Feng Wu, Yandong Ren, Hui Xiang, Sichun Zheng, Lin Liu, Lihua Huang, Baojuan Zeng, Sheng Li, Qingyou Xia, Qisheng Song, Subba Reddy Palli, Qili Feng. BmILF and i-motif structures are involved in transcriptional regulation of BmPOUM2 in Bombyx mori. Nucleic Acids Research, 2018, 46(4):1710-1723.

2. Kangkang Niu, Lijun Xiang, Ying Jin, Yuling Peng, Feng Wu, Wenhuan Tang, Xiaojuan Zhang, Huimin Deng, Hui Xiang, Sheng Li, Jian Wang, Qisheng Song, Qili Feng. Identification of LARK as a novel and conserved G-quadruplex binding protein in invertebrates and vertebrates. Nucleic Acids Research, 2019, 47(14):7306-7320.

3. Lijun Xiang, Kangkang Niu*, Yuling Peng, Xiaojuan Zhang, Xiaoyu Li, Ruoqi Ye, Guoxing Yu, Guojun Ye, Hui Xiang, Qisheng Song, Qili Feng*. DNA G-quadruplex structure participates in regulation of lipid metabolism through Acyl-CoA binding protein. Nucleic Acids Research, 2022, 50(12):6953-6967.

4. Kangkang Niu^#, Xiaojuan Zhang^#, Qisheng Song, Qili Feng. G-quadruplex regulation of mRNA translation of VEGFA by RBM4. International Journal of Molecular Sciences, 2022, 23(2), 743.

5. Feng Wu^#, Kangkang Niu^#, Yong Cui^#, Cencen Li, Mo Lyu, Yandong Ren, Yanfei Chen, Huimin Deng, Lihua Huang, Sichun Zheng, Lin Liu, Jian Wang, Qisheng Song, Hui Xiang, Qili Feng. Genome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution. Communications Biology. 2021, 4: 98.

6. Wenhuan Tang^#, Kangkang Niu^#, Guoxing Yu, Ying Jin, Xian Zhang, Yuling Peng, Shuna Chen, Huimin Deng, Sheng Li, Jian Wang, Qisheng Song, Qili Feng. In vivo visualization of the i-motif DNA secondary structure in the Bombyx mori testis. Epigenetics & Chromatin, 2020, 13(1): 12.

7. Huimin Deng^#, Kangkang Niu^# , Jialing Zhang, Qili Feng. BmBR-C Z4 is an upstream regulatory factor of BmPOUM2 controlling the pupal specific expression of BmWCP4 in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2015, 66:42-50.

8. Lijun Xiang, Xiaojuan Zhang, Sheng Li, Qili Feng, Kangkang Niu*. Ratio of the Primers Used in Polymerase Chain Reaction-Stop Analysis Impacts the Resultant Banding Pattern. ACS omega, 2023, 8(40), 37369-37373.

9. Yuling Peng, Kangkang Niu, Guoxing Yu, Mingxi Zheng, Qiulan Wei, Qisheng Song, Qili Feng. Identification of binding domains and key amino acids involved in the interaction between BmLARK and G4 structure in theBmPOUM2promoter in Bombyx mori, Insect science, 2020, 28(4): 929-940.

10. Guoxing Yu, Kangkang Niu, Yuling Peng, Zhenming Liu, Qisheng Song, Qili Feng. Large-scale screening of i-motif binding compounds in the silkworm, Bombyx mori, Biochemical and Biophysical Research Communications, 2022, 589: 9-15.